花椒籽仁油对实验性高脂血症大鼠的防治作用.doc

花椒籽仁油对实验性高脂血症大鼠的防治作用来源：HYPERLINK"javascript:"中国论文下载中心[07-08-1410:37:00]编辑：studa20

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作者：刘永英，王多宁，刘渊声，杨颖，赵雁武，王增禄，杨继庆
【关键词】花椒籽仁油；高脂血症；脂质代谢；血液黏度；氧自由基
Preventiveandtherapeuticaleffectofthekernelofzanthoxylumseedoilonexperimentalhyperlipidemiainrats
【Abstract】AIM:Toinvestigatetheeffectofthekernelofzanthoxylumseedoil（KZSO）onexperimentalhyperlipidemiainratsandtoprobeintothemechanismofpreventiveandtherapeuticaleffectofKZSO.METHODS:ThirtyhealthySDratswererandomlydividedinto3groups,includingcontrolgroup,hyperlipidemiamodelgroupandKZSOgroup.Controlgroupwasfedordinaryforage;modelgroupwasfedhighlipidforage;KZSOgroupwasadministratedintragastricallyKZSObesideshighlipidforage.Bloodsampleswereobtainedbycuttingnecksafter10weekfeeding.Thelevelsofbloodlipidsandthehemorheologicalparametersweredetermined,andtheactivitiesofsuperoxidedismutase(SOD)andcatalase(CAT),thecontentofmalondialdehyde(MDA)andtherestrainingabilitytohydroxylfreeradical(RAHFR)inthelivertissuesweremeasured.RESULTS:Comparedwiththemodelgroup,cholesterol,triglyceride,highbloodviscosity，andlowbloodviscosityoftheKZSOgroupweredecreased(P<0.05,P<0.01),highdensitylipoproteincholesterolwasincreased(P<0.05).TheactivitiesofSODandCATandtheRAHFRinthelivertissuesofKZSOgroupwereincreased(P<0.05，P<0.01)andthecontentofMDAwasdecreased(P<0.05)ascomparedwiththemodelgroup.CONCLUSION:KZSOcanmodulatethebloodlipid,improvetheindexesinhemorheologyandpreventlipidhyperoxidation.Themechanismmayberelatedtoitscomponentialeffects.
【Keywords】kernelofzanthoxylumseedsoil;hyperlipidemia;lipidmetabolism;bloodviscosity;oxygenfreeradical
【摘要】目的：研究花椒籽仁油对实验性高脂血症大鼠脂质代谢的影响，探讨其对高脂血症的防治作用机制.方法：30只健康SD大鼠随机分为3组：对照组、高脂模型组及花椒油组，对照组普通饲料喂养，其余两组均高脂饲料喂养，花椒油组同时给予花椒籽仁油灌胃，10wk后断颈取血，进行血脂、流变学检测，取肝组织测定SOD,CAT活性、MDA含量及抑制羟自由基能力.结果：与模型组相比,花椒油组的CHOL，TG，HBV，LBV降低(P<0.05，P<0.01)，HDLC增高(P<0.05)，而肝组织匀浆的SOD，CAT活性及抑制羟自由基能力均增强(P<0.05，P<0.01)，MDA含量降低（P<0.05）.结论：花椒籽仁油具有调节血脂、改善血流变、防止脂质过氧化的作用，其作用机制与其主要成分多不饱和脂肪酸的作用有关.
【关键词】花椒籽仁油；高脂血症；脂质代谢；血液黏度；氧自由基
0引言
动脉粥样硬化（arteriosclerosis,AS）是临床上最常见的疾病之