预览加载中，请您耐心等待几秒...

NKAP在脑胶质瘤中的作用及其调控机制的研究.docx

预览
1/2
2/2

在线预览结束，喜欢就下载吧，查找使用更方便

下载提示 文本预览

如果您无法下载资料，请参考说明：

1、部分资料下载需要金币，请确保您的账户上有足够的金币

2、已购买过的文档，再次下载不重复扣费

3、资料包下载后请先用软件解压，在使用对应软件打开

NKAP在脑胶质瘤中的作用及其调控机制的研究 Title:RoleandRegulatoryMechanismsofNKAPinGlioblastoma Introduction: Glioblastomaisthemostcommonandaggressivetypeofprimarybraintumor,withadismalprognosis.Despiteadvancementsintherapeuticapproaches,thesurvivalrateforglioblastomaremainsextremelylow.Thus,thereisanurgentneedtoexplorenovelmoleculartargetsforthediagnosis,prognosis,andtreatmentofglioblastoma.ThispaperaimstoinvestigatetheroleandregulatorymechanismsofNKAP(NFKBActivatingProtein)inglioblastoma,focusingonitspotentialasatherapeutictarget. RoleofNKAPinGlioblastoma: NKAP,atranscriptionalregulator,hasbeenimplicatedinvariouscellularprocesses,includingembryogenesis,immuneresponsemodulation,andcancerprogression.RecentstudieshaveidentifiedNKAPasacriticalmediatorofglioblastomainitiation,progression,andresistancetotherapy.ElevatedexpressionofNKAPhasbeenobservedinglioblastomatissuecomparedtonormalbraintissue,suggestingitspotentialinvolvementintumorigenesis. NKAP-mediatedCancerPathways: NKAPisinvolvedinnuclearfactor-κB(NF-κB)signaling,whichisessentialforglioblastomadevelopmentandprogression.NF-κBactivationpromotestheexpressionofgenesinvolvedincellproliferation,survival,angiogenesis,andinvasion.Throughitsinteractionwithtranscriptionfactorsandco-regulators,NKAPenhancesNF-κBactivity,leadingtotheupregulationofpro-tumorigenicgenes.Furthermore,NKAPhasbeenfoundtointeractwithchromatinremodelingcomplexes,suggestingitsroleinepigeneticregulationofgeneexpressioninglioblastoma. RegulationofNKAPExpression: TheexpressionofNKAPistightlyregulatedbyvariousmechanisms,includingtranscriptional,post-transcriptional,andpost-translationalregulation.Multiplesignalingpathways,suchasMAPK,PI3K/Akt,andWnt/β-catenin,havebeenidentifiedtomodulateNKAPexpressioninglioblastoma.Moreover,microRNAs(miRNAs)haveemergedasessentialregulatorsofNKAPexpression.SeveralmiRNAs,suchasmiR-21andmiR-34a,havebeenshowntodirectlytargetNKAPandregulateitsexpressioninglioblastoma. NKAPasaTherapeuticTarget: Givenitscrucialroleinglioblastomaprogression,NKAPrep