Cdc6参与肿瘤细胞干性及去甲斑蝥素诱导肿瘤干细胞凋亡.docx

Cdc6参与肿瘤细胞干性及去甲斑蝥素诱导肿瘤干细胞凋亡
Title:TheInvolvementofCDC6inTumorCellStemnessandDemethoxycurcumin-InducedApoptosisinTumorStemCells
Abstract:
Cancerstemcells(CSCs)playacrucialroleintumorinitiation,progression,anddrugresistance.TargetingCSCshasemergedasapromisingstrategyforcancertreatment.CDC6,akeyregulatorofDNAreplication,hasbeenfoundtocontributetothemaintenanceofCSCsinvariouscancertypes.Additionally,demethoxycurcumin(DMC),aderivativeofcurcumin,hasshownpotentialinselectivelytargetingCSCsandinducingapoptosis.ThisreviewdiscussestheroleofCDC6intumorcellstemnessandtheeffectofDMContheinductionofapoptosisintumorstemcells.Understandingthemechanismsunderlyingtheseprocessesisessentialforthedevelopmentofeffectivetherapeuticstrategiesagainstcancer.
1.Introduction:
1.1CancerStemCells:
1.2SignificanceofTargetingCSCs:
1.3RoleofCDC6inCSCMaintenance:
1.4PotentialofDMCinTargetingCSCs:
2.CDC6andTumorCellStemness:
2.1OverviewofCDC6:
2.2CDC6inCSCMaintenance:
2.3MechanismsofCDC6-MediatedCSCRegulation:
3.Demethoxycurcumin(DMC)andCSCApoptosis:
3.1OverviewofDMC:
3.2SelectiveTargetingofCSCsbyDMC:
3.3InductionofCSCApoptosisbyDMC:
3.4MolecularMechanismsofDMC-InducedCSCApoptosis:
4.CDC6andDMCCombinationTherapy:
4.1RationaleforCombinationTherapy:
4.2SynergisticEffectsofCDC6InhibitionandDMCTreatment:
4.3PotentialMechanismsofCDC6andDMCCombinationTherapy:
5.Conclusion:
5.1RecapitulationofKeyFindings:
5.2ImplicationsforFutureResearch:
5.3TherapeuticPotentialofCombatingCSCsthroughCDC6andDMCTargeting:
Inconclusion,targetingCSCshasemergedasakeystrategyincancertherapy.CDC6hasbeenidentifiedasaregulatorofCSCmaintenance,whileDMChasshownpotentialinselectivelytargetingCSCsandinducingapoptosis.CombiningCDC6inhibitionandDMCtreatmentmayofferasynergisticeffectincombatingCSCsandimprovingtherapeuticoutcomes.Furtherresearchisneededtoelucidatetheunderlyingmolecularmechanismsandvalidatetheefficacyofthiscombinedapproachinpreclinicalandclinicalsettings.UnderstandingthecomplexinterplaybetweenCDC6andDMCwillcontributetothedev