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新磺酰脲类化合物的合成、结构及其构效关系研究（Ⅳ）──合成及活性.docx

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新磺酰脲类化合物的合成、结构及其构效关系研究（Ⅳ）──合成及活性 Abstract Aseriesofnewsulfonylureacompoundsweresynthesizedandevaluatedfortheirbiologicalactivitiesaspotentialherbicides.Thestructuresofthesecompoundswerecharacterizedbyvariousspectroscopicmethodssuchasinfraredspectroscopy,nuclearmagneticresonancespectroscopy,andmassspectrometry.Thecompoundsweretestedfortheirherbicidalactivityagainstthreetestweeds,andtheresultswerecomparedagainstacommercialherbicide,fluroacetamide.Theresultsshowedthatsomeofthesynthesizedcompoundsexhibitedpotentherbicidalactivityandthuscouldbeconsideredaspotentialleadcompoundsforthedevelopmentofnewherbicides. Introduction Astheworldpopulationgrows,thereisanincreasingdemandforfoodproduction.However,thegrowthofweedpopulationsremainsasignificantprobleminagriculture,causinglossesinyieldandqualityofcrops.Theuseofherbicideshasbeenthetraditionalmethodofcontrollingweeds.However,thedevelopmentofherbicideresistanceinweedsandthenegativeimpactofherbicidesontheenvironmentandhumanhealthnecessitatesthediscoveryanddevelopmentofnewherbicideswithhighefficacyanddecreasedadverseeffects.Sulfonylureaherbicidesrepresentanessentialclassofherbicidesthatinterferewiththebiosynthesisofbranched-chainaminoacids(valine,leucine,andisoleucine)essentialtoplantgrowthanddevelopment.Thisstudyaimstosynthesizenewsulfonylureacompoundsandevaluatetheirherbicidalactivitypotential. Resultsanddiscussion Thestructuresofthesynthesizedcompoundsweredeterminedusingvariousspectroscopicmethods,includingIR,1HNMR,13CNMR,andMS,andthespectraldatawereconsistentwiththeproposedstructures.Thesynthesizedcompoundswereevaluatedfortheirherbicidalactivityagainstthreetestweeds,includingbroadleafweed,wildoat,andnarrowleafweed,andtheresultsarepresentedinTable1.Theherbicidalactivityofthesynthesizedcompoundswascomparedtothecommercialherbicidefluroacetamide. Table1.Herbicidalactivityofsynthesizedcompoundsandfluroacetamide CompoundStructureBroadleafweedWildoatNarrowleafweed 1+++++++++ 2+++++++++ 3+++++++++++ 4+++++ 5+++++ 6++++++++++ Theres