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基于GrC模型的经颅磁声电刺激对神经元放电活动的影响.docx

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基于GrC模型的经颅磁声电刺激对神经元放电活动的影响 Title:TheImpactofTranscranialMagnetic-Acoustic-ElectricStimulationonNeuronalFiringActivity:AGrCModel-BasedApproach Abstract: Transcranialmagnetic-acoustic-electricstimulation(TMAES)hasemergedasanon-invasivetechniqueformodulatingneuronalactivityinthebrain.ThispaperfocusesonanalyzingtheimpactofTMAESonneuronalfiringactivityusingtheGrC(GranuleCell)model.TheGrCmodelallowsforabetterunderstandingoftheunderlyingmechanismsandinteractionsbetweenthestimulationparametersandneuronalresponses.ThisresearchprovidesinsightsintothepotentialofTMAESasatherapeutictoolforvariousneurologicaldisorders. Introduction: TMAESisamultimodalneuromodulationtechniquethatcombinestranscranialmagneticstimulation(TMS),transcranialacousticstimulation(TAS),andtranscranialelectricstimulation(TES).Thiscombinationofmodalitiesprovidesauniqueopportunitytomodulateneuronalfiringactivityandinvestigateitseffects.TheuseoftheGrCmodelallowsforacomprehensiveexplorationofhowTMAESinfluencesthefunctioningofneuronalnetworks. Methods: TheGrCmodelsimulatesthebehaviorofgranulecells,whichareimportantelementsinthecerebellum.ThismodelintegratestheeffectsofTMAESstimulationparameters,includingmagneticfieldintensity,acousticfrequency,andelectriccurrentamplitude,onneuronalfiringactivity.Byvaryingtheseparameters,theirindividualandcombinedeffectscanbeexplored. Results: StudiesusingtheGrCmodelhavedemonstratedthatTMAEScansignificantlymodulateneuronalfiringactivity.Magneticstimulationhasbeenshowntoinduceactionpotentialsingranulecellsbydepolarizingtheneuronalmembrane.Acousticstimulationaffectsthetimingandsynchronizationofneuronalfiring,whileelectricstimulationinfluencesthemembranepotentialthresholdsforactionpotentials.Furthermore,thecombinedeffectofTMAEScouldpotentiateorinhibitfiringactivity,dependingonthespecificparametersused. Discussion: ThefindingsfromGrCmodel-basedstudiesindicatethatTMAEShasthepotentialtomodulatethefiringactivityofneuronalnetworks.Thismodulationcanhavevariousapplicationsinthefieldofbraind