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Box-Behnken响应面法优化疏水改性普鲁兰纳米粒的制备工艺.docx

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Box-Behnken响应面法优化疏水改性普鲁兰纳米粒的制备工艺 Title:OptimizationofHydrophobicModificationofPrunelanaonoParticleUsingBox-BehnkenResponseSurfaceMethodology Abstract: ThehydrophobicmodificationofPrunelananoparticlesplaysacrucialroleinenhancingtheirstabilityanddispersibilityinaqueoussystems.Inthisstudy,theBox-Behnkenresponsesurfacemethodology(RSM)wasemployedtooptimizetheprocessparametersforthehydrophobicmodificationofPrunelananoparticles.Theobjectivewastoachievemaximumhydrophobicitywhileminimizingtheuseofchemicalmodifiers.Theindependentvariables,includingreactiontime,reactiontemperature,andconcentrationofthehydrophobicagent,weresystematicallyinvestigated.Theoptimizedprocesswasidentified,andthehydrophobicmodifiedPrunelananoparticleswerecharacterizedviavarioustechniques,suchasFourierTransformInfraredspectroscopy(FTIR),X-raydiffraction(XRD),scanningelectronmicroscopy(SEM),andcontactanglemeasurements.TheresultsshowedthattheBox-BehnkenRSMeffectivelyoptimizedthehydrophobicmodificationprocessofPrunelananoparticles. 1.Introduction: Prunelananoparticleshavegainedsignificantattentionduetotheiruniqueproperties,suchashighsurfacearea,highmechanicalstrength,andgoodthermalstability.However,theirhydrophilicnaturelimitstheiruseinvariousapplications.Toovercometheselimitations,hydrophobicmodificationofPrunelananoparticlesisnecessary.ThehydrophobicsurfacemodificationcanenhancethecompatibilityanddispersibilityofPrunelananoparticlesinhydrophobicmatrices,makingthemsuitableforapplicationsinareassuchasdrugdelivery,coatings,andsensors.Therefore,optimizingthehydrophobicmodificationprocessiscrucialtoobtainPrunelananoparticleswithdesirableproperties. 2.ExperimentalDesign: TheBox-Behnkendesignisatypeofresponsesurfacemethodologywidelyusedforoptimizingexperimentalparameters.Thisdesignallowstheexplorationoftheexperimentalspacetoidentifytheoptimumconditions.Inthisstudy,threeindependentvariableswereconsidered:reactiontime(X1),reactiontemperature(X2),andconcentrationofthehydrophobicagent(X3).Threelevelswereselectedfor