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Oncomine数据库在肿瘤研究中的应用.docx

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Oncomine数据库在肿瘤研究中的应用 Introduction Cancerresearchhasbeenachallengingendeavorinthefieldofmedicineduetothecomplexityofthedisease.Withtheadventofhigh-throughputtechnologies,ithasbecomepossibletoinvestigatethemolecularbasisofcanceratagreaterdepth,leadingtotheidentificationofkeygenomicalterationsandtargetablepathways.Oncominedatabaseisaweb-basedtoolthathasbeendevelopedtoprovideaplatformfortheanalysisoflarge-scalecancergenomicsdata.Inthispaper,wewillexploretheuseofOncomineincancerresearch,highlightingitsapplicationsintheidentificationofnewdrugtargets,biomarkerdiscovery,andmolecularprofiling. OncomineDatabase OncomineisaproprietarycancergenomicsdatabasethathasbeendevelopedandmaintainedbyThermoFisherScientific.Itisaweb-basedplatformthathostscomprehensivegeneexpressiondatasetsfromvariouscancertypes,withtheaimoffacilitatingtranslationalresearch.Thedatabaseleveragesonthepowerofmicroarrayandnext-generationsequencing(NGS)technologiestogeneratehigh-quality,curateddatafromthousandsofpatientsamples.Oncomineplatformprovidesresearcherswithauser-friendlyinterfacetoaccessandanalyzethisdataforarangeofapplications. ApplicationsofOncomineinCancerResearch DrugTargetIdentification OneofthemajorapplicationsofOncomineincancerresearchisintheidentificationofnewdrugtargets.GeneexpressiondataobtainedfromOncominehasbeenwidelyusedtoidentifygenedriversthatareresponsibleforthegrowthandproliferationofcancercells,particularlythosethatareinvolvedinsignalingpathwayssuchasPI3K/AKT/mTORandRAS/ERK.Thesepathwayshavebeenshowntobedysregulatedinmanycancertypes,henceprovidingpromisingtargetsforcancertherapy. Forinstance,inastudybyWangetal.(2020),Oncominedatabasewasusedtoanalyzegeneexpressiondatafrombladdercancerpatientsinordertoidentifypotentialtherapeutictargets.ThestudyidentifiedthePIK3CAgeneasapotentialdrugtarget,withtheauthorssuggestingthatinhibitorsofthisgenecouldbeusedtotreatbladdercancerpatients. BiomarkerDiscovery Oncominedatabasehasalsobeenwidelyusedinbiomarkerdiscovery.Byanalyzinggeneexpressiondatafromd