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鱼藤酮对大鼠肝毒性及其线粒体损伤机制的研究.docx

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鱼藤酮对大鼠肝毒性及其线粒体损伤机制的研究 Title:StudyonHepatotoxicityofFishVinegarKetoneanditsMechanismofMitochondrialDamageinRats Abstract: Therapiddevelopmentandwidespreadusageoftraditionalherbalmedicineshasraisedconcernsovertheirpotentialadverseeffectsonliverfunction.ThisstudyaimedtoinvestigatethehepatotoxicityofFishVinegarKetone(FVK)anditsunderlyingmechanismsofmitochondrialdamageinrats.Inthisstudy,maleWistarratswereorallyadministeredwithvaryingdosesofFVKfor28consecutivedays,andchangesinliverhistopathology,liverfunction,oxidativestressmarkers,andmitochondrialultrastructurewereevaluated.TheresultsrevealedthatFVKtreatmentcauseddose-dependentliverinjury,asevidencedbysignificantalterationsinliverenzymelevels,hepatichistopathologicalchanges,andcompromisedliverfunction.Furthermore,FVKinducedanimbalanceintheantioxidantsystem,leadingtoelevatedoxidativestress,asindicatedbysignificantlyincreasedlevelsofmalondialdehyde(MDA)anddecreasedlevelsofantioxidantenzymes.Notably,FVKtreatmentalsoresultedinmitochondrialdysfunction,includingdisruptionofmitochondrialmembranepotential,morphologicalabnormalities,anddeclinedmitochondrialrespiratoryfunction.Additionally,FVKexposurecausedasignificantdecreaseintheexpressionofmitochondrialfusionproteins(MFN1andMFN2),whileupregulatingtheexpressionofmitochondrialfissionprotein(DRP1).ThesefindingssuggestthatFishVinegarKetoneinduceshepatotoxicityinrats,possiblybyinducingoxidativestressandimpairingthemitochondrialdynamics. Introduction: Traditionalherbalmedicineshavebeenwidelyusedfortheirtherapeuticproperties.However,thepotentialadverseeffectsofthesemedicinesonliverfunctioncannotbeoverlooked.FishVinegarKetone(FVK)isatraditionalherbalmedicinecommonlyusedinfolkmedicinetotreatvariousdiseases.Despiteitsmedicinalbenefits,thereislimitedinformationonitspotentialhepatoxicityandtheunderlyingmechanismsinvolved.Therefore,thisstudyaimstoinvestigatethehepatotoxiceffectsofFVKandexploreitsimpactonmitochondrialdamageinrats. MaterialsandMethods: 1.Animaltreatment:MaleWistarratsweredivi