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酪素基中空纳米复合乳液的制备与性能研究.docx

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酪素基中空纳米复合乳液的制备与性能研究 Title:PreparationandPerformanceStudyofLactoferrin-LoadedHollowNanocompositeEmulsion Abstract: Thepresentstudyfocusesonthepreparationandperformanceanalysisoflactoferrin-loadedhollownanocompositeemulsion.Lactoferrin,amultifunctionalproteinwithpotentialbioactivities,wasencapsulatedwithinhollownanoparticlestoenhanceitsstabilityandcontrolledreleaseproperties.Theaimofthisresearchwastoinvestigatethesynthesisprocessofthelactoferrin-loadedhollownanocompositeemulsion,aswellastoevaluateitsphysicochemicalproperties,releasebehavior,andpotentialapplications. Introduction: Lactoferrinisaglycoproteinfoundinmammalianmilkandotherbodilysecretions.Itexhibitsvariousbiologicalactivities,suchasantimicrobial,anticancer,andimmunomodulatoryeffects.However,lactoferrin'sstabilityandcontrolledreleasepropertiesareconsideredmajorchallengesforitspracticalapplications.Toovercometheselimitations,theencapsulationoflactoferrinwithinhollownanoparticleshasbeenproposedasapromisingstrategy.Thehollownanocompositeemulsioncanprotectlactoferrinfromdegradation,providecontrolledreleasekinetics,andimproveitsbioavailability. Methodology: Thesynthesisoflactoferrin-loadedhollownanocompositeemulsioninvolvedatwo-stepprocess:formationofhollownanoparticlesandsubsequentloadingoflactoferrin.Hollownanoparticleswerefabricatedusingatemplate-assistedmethod,employingasacrificialtemplatematerial.Thetemplatewasremoved,resultinginhollowstructuresthatwerethencoatedwithananocompositetoformthefinalemulsion.Theeffectofvariousparameters,suchastheconcentrationofthetemplatematerial,lactoferrin-to-templateratio,andemulsioncomposition,onthesizeandmorphologyofthehollownanocompositeemulsionwerecarefullyoptimized. ResultsandDiscussion: Characterizationstudies,includingtransmissionelectronmicroscopy(TEM)anddynamiclightscattering(DLS),confirmedthesuccessfulsynthesisoflactoferrin-loadedhollownanocompositeemulsion.TEManalysisrevealeduniformandsphericalhollowstructures,withanaveragediameterofXXnm.DLSmeasurementsindicatedthatt