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环氧广藿香烯抗炎及抗胃溃疡的药效及机制研究.docx

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环氧广藿香烯抗炎及抗胃溃疡的药效及机制研究 Title:TheAnti-inflammatoryandAnti-gastricUlcerEffectsofCineole:AStudyonItsPharmacologicalMechanisms Abstract: Cineole,alsoknownaseucalyptol,isanaturalorganiccompoundfoundinmanyaromaticplants,includingrosemary,eucalyptus,andsage.Thispapercomprehensivelyinvestigatesthemedicinalpropertiesofcineole,focusingonitsanti-inflammatoryandanti-gastriculcereffectsandtheunderlyingmechanisms.Throughareviewofexistingliterature,thisstudyhighlightsthepotentialofcineoleasatherapeuticagentforthetreatmentofinflammatoryconditionsandgastriculcers. Keywords:cineole,eucalyptol,anti-inflammatory,anti-gastriculcer,pharmacologicalmechanisms 1.Introduction Inflammatorydiseasesandgastriculcersareprevalenthealthissuesworldwide.Thesearchforeffectivetreatmentswithminimalsideeffectshasledtoanincreasedinterestinnaturalcompoundswithpotentialmedicinalproperties.Cineole,acyclicether,hasgainedattentionduetoitspotentialtherapeuticeffects,includinganti-inflammatoryandanti-gastriculcerproperties.Thispaperaimstoprovideacomprehensiveoverviewofthepharmacologicalmechanismsunderlyingcineole'seffectsanditspotentialfortherapeuticuse. 2.Anti-inflammatoryEffectsofCineole 2.1.InhibitionofPro-inflammatoryMediators a.Cineoleinhibitstheproductionofpro-inflammatorycytokinessuchastumornecrosisfactor-alpha(TNF-α),interleukin-1beta(IL-1β),andinterleukin-6(IL-6). b.Cineolesuppressestheactivationoftranscriptionfactors,includingnuclearfactor-kappaB(NF-κB),whichregulatestheexpressionofpro-inflammatorygenes. c.Cineolemodulatestheactivityofenzymesinvolvedintheinflammatoryprocess,suchascyclooxygenase-2(COX-2)andinduciblenitricoxidesynthase(iNOS). 2.2.Anti-oxidativeEffects a.Cineoleexhibitsantioxidantpropertiesbyscavengingreactiveoxygenspecies(ROS)andinhibitinglipidperoxidation,thusreducingoxidativestress-inducedinflammation. b.Cineoleincreasesendogenousantioxidantdefenses,includingsuperoxidedismutase(SOD),catalase,andglutathioneperoxidase(GPx). 3.Anti-gastricUlcerEffectsofCineole 3.1.GastricAcidRegulation a.C