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LncRNACYTOR、EGFR调控肝癌细胞增殖、迁移的研究.docx

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LncRNACYTOR、EGFR调控肝癌细胞增殖、迁移的研究 LncRNACYTORisarecentlydiscoveredlongnon-codingRNAthathasbeenlinkedtovariouscellularprocesses,includingcancerdevelopment.Inthispaper,wewillexploretheregulatoryroleoflncRNACYTORandEGFRinlivercancercellproliferationandmigration. Livercancer,particularlyhepatocellularcarcinoma(HCC),isoneofthemostcommonlydiagnosedcancertypesworldwideandisassociatedwithhighmortalityrates.Thedysregulationofgenesandnon-codingRNAs,suchaslncRNACYTOR,playsacrucialroleintheinitiationandprogressionoflivercancer. LncRNACYTOR,alsoknownasCYTORorLINC00152,islocatedonchromosome2p11.2andishighlyexpressedinlivercancercells.SeveralstudieshaveshownthatlncRNACYTORpromotestumorproliferationbyregulatingvarioussignalingpathways.Additionally,lncRNACYTORhasbeenfoundtobeassociatedwiththeEpidermalGrowthFactorReceptor(EGFR),akeyregulatorofcellgrowthandsurvival. EGFRisatransmembraneproteinthatplaysacriticalroleinsignalingcascadesinvolvedincellproliferationandmigration.EGFRactivationtriggersacomplexseriesofevents,includingtheactivationofdownstreamsignalingpathwayssuchastheRAS-RAF-MAPKpathwayandthePI3K-AKT-mTORpathway.DysregulationofEGFRsignalinghasbeenimplicatedinthedevelopmentofvariouscancers,includinglivercancer. RecentstudieshavesuggestedthatlncRNACYTORcanregulateEGFRexpressionandactivityinlivercancercells.IthasbeenobservedthatlncRNACYTORcaninteractwithmiRNAs,suchasmiR-138,miR-195,andmiR-196a,tomodulateEGFRexpression.ThesemiRNAsareknowntotargetEGFRmRNA,resultingindecreasedEGFRlevels.BysequesteringthesemiRNAs,lncRNACYTORactsasaspongeandpreventstheirbindingtoEGFRmRNA,therebyincreasingEGFRexpression. TheupregulationoflncRNACYTORandEGFRinlivercancercellshasbeenshowntopromotecellproliferationandmigration.StudieshavedemonstratedthatknockingdownlncRNACYTORorinhibitingEGFRexpressionleadstoadecreaseincellviability,colonyformation,andmigrationabilityoflivercancercells.Furthermore,theoverexpressionoflncRNACYTORoractivationofEGFRsignalinghasbeenassociatedwithpoorprognosisandadvancedtumorstagei