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组蛋白赖氨酸酰化新修饰研究进展.docx

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组蛋白赖氨酸酰化新修饰研究进展 Title:RecentAdvancesinArginineAcetylation,aNovelPost-translationalModificationofHistones Abstract: Post-translationalmodifications(PTMs)playcriticalrolesinregulatingthestructureandfunctionofhistones,theproteinsresponsibleforpackagingandorganizingtheeukaryoticgenome.OneemergingunderstudiedPTMisarginineacetylation,whichinvolvesthetransferofanacetylgrouptotheε-aminogroupofarginineresidues.Inthispaper,wereviewtherecentresearchprogressonarginineacetylationanditsimpactonchromatinstructure,genetranscription,andcellularprocesses.WealsodiscussthecrosstalkbetweenarginineacetylationandotherhistonePTMs,aswellasthepotentialimplicationsofdysregulatedarginineacetylationindiseases.Thisreviewprovidesvaluableinsightsintothebiologicalsignificanceofarginineacetylationandhighlightspotentialavenuesforfutureresearch. 1.Introduction HistonesarekeyproteinsinvolvedinthepackagingofDNAintochromatinandplayacrucialroleinregulatinggeneexpression.Toachievethis,histonesundergoawiderangeofPTMs,includingmethylation,acetylation,phosphorylation,andubiquitination.Whileargininemethylationhasbeenextensivelystudied,theimportanceandpotentialfunctionsofarginineacetylationhaveonlyrecentlyemerged. 2.ArginineAcetyltransferasesandDeacetylases Arginineacetylationismediatedbyenzymesknownasarginineacetyltransferases(ARTs)andcanbereversedbyargininedeacetylases,suchassirtuins.ThissectionexploresthediscoveryofARTsandtheirrolesinchromatinremodelingandgeneregulation. 3.CrosstalkbetweenArginineAcetylationandOtherPTMs HistonePTMsoftenexhibitcrosstalk,whereonemodificationinfluencestheoccurrenceorfunctionofanother.WediscusstheinterplaybetweenarginineacetylationandotherPTMs,includinglysineacetylationandmethylation,andthepotentialimplicationsongeneexpressionandcellularprocesses. 4.BiologicalFunctionsofArginineAcetylation Thefunctionalsignificanceofarginineacetylationincellularprocesses,suchasDNAdamagerepair,transcriptionalregulation,andalternativesplicing,isdiscussedinthissection.Wehighlightthemechanismsbywhic