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绝经后甲状腺结节的雌激素水平与雌激素代谢相关基因的表达.docx

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绝经后甲状腺结节的雌激素水平与雌激素代谢相关基因的表达 Title:TheAssociationbetweenEstrogenLevelsandExpressionofEstrogenMetabolism-RelatedGenesinPostmenopausalThyroidNodules Abstract: Thecessationofmenstruation,ormenopause,marksasignificantlifetransitionforwomenandisaccompaniedbyadeclineinovarianfunctionandestrogenlevels.Postmenopausalwomenhaveanincreasedriskofdevelopingthyroidnodules,whichareabnormalgrowthsinthethyroidgland.Theaimofthisstudyistoexploretherelationshipbetweenestrogenlevelsandtheexpressionofestrogenmetabolism-relatedgenesinpostmenopausalthyroidnodules.Understandingthisassociationmayprovidevaluableinsightsintothepathogenesisandmanagementofthyroidnodulesinpostmenopausalwomen. Introduction: Thyroidnodulesareprevalentinpostmenopausalwomen,andtheirdevelopmentisbelievedtobeinfluencedbyhormonalchangesassociatedwithmenopause.Estrogen,akeyhormoneprimarilyproducedbytheovaries,playsacrucialroleinthyroidfunction.Estrogenregulatestheexpressionofseveralgenesinvolvedinthemetabolismofhormones,includingthoseinvolvedinestrogenmetabolismpathways.Thealterationofestrogenlevelsandestrogenmetabolism-relatedgeneexpressioninpostmenopausemaycontributetotheoccurrenceandprogressionofthyroidnodules. Methods: 1.PatientSelectionandSampleCollection:Postmenopausalwomendiagnosedwiththyroidnoduleswillberecruitedforthisstudy.Thyroidnoduletissuesampleswillbecollectedthroughthyroidsurgery. 2.HormoneLevelAssessment:Serumestrogenlevelswillbemeasuredusingareliableandvalidatedassaytechnique. 3.GeneExpressionAnalysis:RNAwillbeextractedfromthyroidnoduletissuesamples,andtheexpressionofestrogenmetabolism-relatedgeneswillbeassessedusingquantitativereal-timepolymerasechainreaction(qRT-PCR). 4.StatisticalAnalysis:Correlationanalysiswillbeperformedtoexploretherelationshipbetweenestrogenlevelsandgeneexpression.Additionally,otherconfoundingfactors,suchasage,bodymassindex(BMI),andmenopausalduration,willbetakenintoconsideration. Results: Preliminaryresultsfromthisstudyindicateapotentialcorrelationbetweenestrogenlevelsandtheexpressi