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盐酸法舒地尔预处理联合缺血后处理对离体大鼠心肌缺血再灌注损伤的影响.docx

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盐酸法舒地尔预处理联合缺血后处理对离体大鼠心肌缺血再灌注损伤的影响 Title:TheimpactofPre-treatmentwithSchisandrinCandPost-treatmentwithSalvinorinAonIschemia-ReperfusionInjuryinIsolatedRatMyocardium:AStudyontheProtectiveEffectsofSemicarpusanacardium Abstract: Ischemia-reperfusioninjury(IRI)isasignificantcomplicationinvariouscardiovasculardisorders,leadingtomyocardialdamageandimpairedcardiacfunction.Thisstudyaimedtoinvestigatethecombinedeffectsofpre-treatmentwithSchisandrinC(SC)andpost-treatmentwithSalvinorinA(SA)viathehydrochloricacidmethodonIRIinisolatedratmyocardium.TheprotectiveeffectsoftheherbalextractSemicarpusanacardiumwerealsoevaluated. Keywords:ischemia-reperfusioninjury,SchisandrinC,SalvinorinA,Semicarpusanacardium,myocardium Introduction: Ischemia-reperfusioninjury,characterizedbytherestorationofbloodflowafteraperiodofischemia,canfurtherexacerbatetissuedamageduetooxidativestress,inflammation,andcellulardysfunction.Previousstudieshavedemonstratedthatnaturalcompoundswithantioxidantandanti-inflammatorypropertiescouldofferprotectiveeffectsagainstIRI.SchisandrinC,amajoractivecomponentofSchisandrachinensis,hasbeenreportedtohaveantioxidantproperties,whileSalvinorinA,derivedfromtheherbSemicarpusanacardium,possessesanti-inflammatoryandcardioprotectiveeffects.However,thecombinedeffectsofSCandSAonIRIhavenotbeenthoroughlyinvestigated. Methods: Theexperimentutilizedisolatedratheartssubjectedtoastandardmodelofischemia-reperfusioninjury.Theheartsweredividedintofourgroups:control,SCpre-treatment,SApost-treatment,andcombinedSCpre-treatmentwithSApost-treatment.Theheartsweresubjectedto30minutesofischemiafollowedby60minutesofreperfusion.Functionalparameterssuchasleftventriculardevelopedpressure(LVDP),heartrate(HR),andrate-pressureproduct(RPP)wererecorded.Biomarkersofoxidativestress,suchasmalondialdehyde(MDA)andcatalaseactivity,weremeasured.Additionally,markersofinflammation,includingtumornecrosisfactor-alpha(TNF-α)andinterleukin-6(IL-6),wereevaluated. Results: Theresultsshowedthatpre-treatmentwithSCsignificant