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人脐带沃顿胶间充质干细胞移植治疗对大鼠脑损伤区微循环的影响.docx

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人脐带沃顿胶间充质干细胞移植治疗对大鼠脑损伤区微循环的影响 Title:TheImpactofUmbilicalCordWharton'sJelly-derivedMesenchymalStemCellTransplantationonMicrocirculationinRatBrainInjuryZone Abstract: Braininjuryisamajorcauseofdisabilityandmortalityworldwide.Thecurrenttreatmentoptionsforbraininjuryhavelimitedeffectivenessandthereisaneedfornoveltherapeuticstrategies.Mesenchymalstemcell(MSC)transplantationhasshownpromisingresultsinavarietyofneurologicaldisorders.Inthisstudy,weaimedtoinvestigatetheeffectsofumbilicalcordWharton'sJelly-derivedMSCtransplantationonmicrocirculationinthebraininjuryzoneofrats. Keywords:braininjury,mesenchymalstemcells,Wharton'sJelly,microcirculation,transplantation Introduction: Braininjurycanresultfromtrauma,stroke,orneurodegenerativediseases,anditleadstosignificantfunctionalandstructuraldamageintheaffectedbrainregions.Oneofthekeyfactorscontributingtothepathophysiologyofbraininjuryisimpairedmicrocirculation,whichleadstoreducedoxygenandnutrientsupplytotheinjuredbraintissue.Restorationofmicrocirculationiscrucialforpromotingtissuerepairandfunctionalrecoveryafterbraininjury. Mesenchymalstemcells(MSCs)haveemergedasapotentialtherapeuticoptionforbraininjuryduetotheiruniqueproperties,suchasself-renewal,multipotency,andimmunomodulatoryeffects.Wharton'sJelly,derivedfromtheumbilicalcord,isarichsourceofMSCsandholdsgreatpromiseforregenerativemedicine.TransplantationofWharton'sJelly-derivedMSCshasshownbeneficialeffectsinvariouspreclinicalandclinicalstudiesonbraininjury. Methods: Inthisstudy,weusedaratmodelofbraininjurytoinvestigatetheeffectsofWharton'sJelly-derivedMSCtransplantationonmicrocirculation.Theratswererandomlydividedintotwogroups:acontrolgroupreceivingsalineinjectionandanexperimentalgroupreceivingWharton'sJelly-derivedMSCtransplantation.Thebraininjurywasinducedusingthecontrolledcorticalimpactmodel.Aftertheinjury,MSCsweretransplantedintotheinjuryzoneofratsintheexperimentalgroup. Microcirculatoryparameters,includingcerebralbloodflow,vesseldensity,andblood-brainbarrierpermeability,we