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载脂蛋白A与急性冠脉综合征合并2型糖尿病患者冠脉狭窄程度的相关性研究.docx

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载脂蛋白A与急性冠脉综合征合并2型糖尿病患者冠脉狭窄程度的相关性研究 Title:TheCorrelationBetweenApolipoproteinAandCoronaryArteryStenosisinType2DiabetesPatientswithAcuteCoronarySyndrome Abstract: Objective:ThisstudyaimstoinvestigatethecorrelationbetweenapolipoproteinA(apoA)levelsandthedegreeofcoronaryarterystenosisinpatientswithacutecoronarysyndrome(ACS)andtype2diabetesmellitus(T2DM). Methods:AtotalofXXpatientsdiagnosedwithACSandT2DMwereenrolledinthiscross-sectionalstudy.TheplasmaapoAlevelsweremeasuredbyenzyme-linkedimmunosorbentassay(ELISA).CoronaryangiographywasperformedtoevaluatethedegreeofcoronaryarterystenosisusingtheGensiniscore. Results:TheplasmaapoAlevelswerefoundtobesignificantlylowerinT2DMpatientswithACScomparedtothosewithoutACS(p<0.05).Moreover,therewasanegativecorrelationbetweenapoAlevelsandtheGensiniscore(r=-0.XXX,p<0.05),indicatingthatlowerapoAlevelswereassociatedwithahigherdegreeofcoronaryarterystenosis. Conclusion:OurfindingssuggestthatlowerapoAlevelsareassociatedwithmoreseverecoronaryarterystenosisinT2DMpatientswithACS.FurtherstudiesarenecessarytoexploretheunderlyingmechanismsandevaluatethepotentialofapoAasabiomarkerforcardiovascularriskstratificationinthispatientpopulation. Introduction: Type2diabetesmellitus(T2DM)isasignificantriskfactorforthedevelopmentofcardiovasculardiseases,includingacutecoronarysyndrome(ACS).PatientswithACSandT2DMoftenexhibitmoreseverecoronaryarterystenosisandhaveworseclinicaloutcomescomparedtothosewithoutdiabetes.Therefore,itiscrucialtoidentifyspecificbiomarkersthatcanhelpriskstratificationandguidetreatmentdecisionsinthispatientpopulation. ApolipoproteinA(apoA),themainproteincomponentofhigh-densitylipoprotein(HDL),playsacrucialroleinreversecholesteroltransportandhasbeenlinkedtocardiovascularhealth.LowerlevelsofapoAhavebeenfoundinpatientswithT2DMandhavebeenassociatedwithanincreasedriskofcardiovascularevents.However,therelationshipbetweenapoAlevelsandthedegreeofcoronaryarterystenosisinT2DMpatientswithACSremainsunclear.Therefore,thisstudyaimstoinvestigatethecorr