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表观修饰调控Botrytiscinerea发育和致病力的分子机制.docx

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表观修饰调控Botrytiscinerea发育和致病力的分子机制 Title:MolecularMechanismsofEpigeneticRegulationinModulatingDevelopmentandVirulenceofBotrytiscinerea Abstract: Botrytiscinereaisanecrotrophicphytopathogenicfungusthatcausesdevastatingdiseasesinawiderangeofeconomicallyimportantcrops.Understandingthemolecularmechanismsunderlyingitsdevelopmentandvirulenceiscrucialfordevelopingeffectivestrategiestocombatthispathogen.Recentstudieshavehighlightedtheimportanceofepigeneticregulation,particularlyhistonemodificationsandDNAmethylation,inmodulatingthedevelopmentandvirulenceofB.cinerea.ThisreviewaimstosummarizethecurrentunderstandingofthemolecularmechanismsbywhichepigeneticmodificationsregulatethedevelopmentandvirulenceofB.cinereaandtheirpotentialimplicationsfordiseasemanagement. Introduction: Botrytiscinerea,commonlyknownasgraymold,isamajorpathogenaffectingnumerouscropsworldwide,includingfruits,vegetables,andornamentalplants.Thisnecrotrophicfungusischaracterizedbyitsabilitytoinfectandcolonizehealthyplanttissues,resultinginextensivetissuedamageandeconomiclosses.Despitethesignificanteconomicimpactofthispathogen,themolecularmechanismsunderlyingitsdevelopmentandvirulenceremainpoorlyunderstood.RecentstudieshaveshownthatepigeneticmodificationsplayacrucialroleinregulatingthedevelopmentandvirulenceofB.cinerea. HistoneModificationsinB.cinerea: Histonemodifications,includingacetylation,methylation,phosphorylation,andubiquitination,havebeenimplicatedintheregulationofgeneexpressionandvariousbiologicalprocessesineukaryotes.InB.cinerea,severalhistonemodificationshavebeenidentified,withtheirrolesindevelopmentandvirulencebeinggraduallyelucidated.Forexample,thelossofH3K9methylationinB.cinerealeadstoreducedvirulenceduetothedysregulationofgenesinvolvedinpathogenesis.Additionally,histoneacetylationanddeacetylationareassociatedwithcriticaldevelopmentaltransitionsandtheexpressionofvirulence-relatedgenesinthisfungus. DNAMethylationinB.cinerea: DNAmethylationisanepigeneticmodificationthatplaysavitalroleingeneregulationa