pH敏感型水凝胶的制备及其释药性能研究.docx

pH敏感型水凝胶的制备及其释药性能研究
Title:PreparationandDrugReleasePerformanceStudyofpH-SensitiveHydrogel
Abstract:
Hydrogelshaveattractedsignificantattentioninthefieldofdrugdeliveryduetotheiruniquepropertiessuchasexcellentbiocompatibility,highwatercontent,andtunabledrugreleasecharacteristics.Inthisstudy,pH-sensitivehydrogelswerepreparedandtheirdrugreleaseperformancewasinvestigated.Thehydrogelsweresynthesizedusingacombinationofnaturalpolymersandcrosslinkingagents,andtheirphysicochemicalproperties,swellingbehavior,anddrugreleasekineticswereevaluated.TheresultsshowedthatthepH-sensitivehydrogelsexhibitedexcellentpH-responsivenessandcontrolleddrugrelease,makingthempromisingcandidatesfortargeteddrugdeliverysystems.
1.Introduction
1.1Background
1.2Objectivesandsignificanceofthestudy
2.MaterialsandMethods
2.1Materials
2.2SynthesisofpH-sensitivehydrogels
2.3Characterizationofhydrogels
2.4Drugloadingandreleasestudies
3.ResultsandDiscussion
3.1PhysicochemicalpropertiesofpH-sensitivehydrogels
3.2Swellingbehaviorofhydrogels
3.3Drugreleasekinetics
3.4MechanismofpHsensitivityanddrugrelease
4.Conclusion
4.1Summaryoffindings
4.2Implicationsandfuturedirections
Acknowledgments
References
1.Introduction
1.1Background
Hydrogelsarethree-dimensional,crosslinkedpolymericnetworksthathavetheabilitytoabsorbandretainlargeamountsofwater.Theyhavebeenextensivelystudiedforvariousbiomedicalapplications,includingdrugdeliverysystems.Unlikeconventionaldrugdeliverysystems,hydrogelscanprovidesustainedandcontrolleddrugreleaseoveranextendedperiod,reducingthefrequencyofdosingandimprovingpatientcompliance.However,toachieveprecisecontroloverdrugrelease,itisnecessarytodesignhydrogelsthatrespondtospecificenvironmentalstimuli,suchaschangesinpH,temperature,orpresenceofenzymes.Amongthem,pH-sensitivehydrogelshavegainedsignificantattentionduetotheirabilitytoreleasedrugsinresponsetochangesinpH,makingthemsuitablefortargeteddrugdelivery.
1.2Objectivesandsignificanceofthestudy
TheobjectiveofthisstudywastopreparepH-sensitivehydrogelsu