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CDC42在人类早期胚胎发育中的作用机制.docx

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CDC42在人类早期胚胎发育中的作用机制 Title:TheRoleandMechanismofCDC42inEarlyHumanEmbryonicDevelopment Abstract: Earlyembryonicdevelopmentisahighlyorchestratedprocessinvolvingaseriesofcomplexcellularandmolecularevents.AmongthemoleculescriticalforembryogenesisisCDC42,amemberoftheRho-GTPasefamily,whichregulatesvariouscellularprocesses,includingcellpolarity,celldivision,anddifferentiation.ThispaperaimstoreviewthecurrentunderstandingoftheroleandmechanismofCDC42inearlyhumanembryonicdevelopment. Introduction: Earlyembryonicdevelopmentencompassestheseriesofeventsfromfertilizationtotheformationofthethreegermlayers:ectoderm,mesoderm,andendoderm.Thisprocessinvolvescelldivision,migration,andorganization,ultimatelygivingrisetoalltissuesandorgansinthehumanbody.CDC42,asakeyregulatorofcellpolarityandcytoskeletonorganization,playsavitalroleintheseprocesses. RoleofCDC42inEarlyHumanEmbryonicDevelopment: 1.CellPolarity: Cellpolarityisessentialfortheestablishmentoftheembryonicaxisandpropertissuepatterning.CDC42isinvolvedinestablishingcellpolarityduringearlyembryogenesisthroughtheregulationofapical-basalcellpolarityandplanarcellpolarity(PCP).CDC42activationiscrucialfortheformationofdistinctapicalandbasolateralcompartmentsinembryoniccells,whichisnecessaryfortissuedifferentiation. 2.CellDivision: Propercelldivisioniscriticalforthedevelopmentoftheembryo.CDC42regulatescelldivisionbycoordinatingmitoticspindlepositioningandcytokinesis.Intheearlystagesofembryonicdevelopment,CDC42isinvolvedindeterminingtheorientationofthemitoticspindle,ensuringthecorrectdistributionofcellfatedeterminants.Additionally,CDC42isalsoimplicatedintheregulationofcytokinesis,ensuringtheevendistributionofcellularcontenttodaughtercells. 3.CellMigration: Cellmigrationisfundamentalfortissuemorphogenesisduringembryonicdevelopment.CDC42-mediatedcytoskeletaldynamicsareessentialforpropercellmigrationandtissuepatterning.CDC42regulatesactinpolymerizationandreorganization,necessaryforcellularprotrusionformationanddirectionalmovement.Itcollaborates