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抗肿瘤活性物质的筛选及其抗肿瘤机制的研究.docx

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抗肿瘤活性物质的筛选及其抗肿瘤机制的研究 Abstract: Tumorisoneofthemostseriousdiseasesthatthreatenhumanhealth.Inrecentyears,thesearchforanti-tumoractivesubstanceshasbecomeahotspotindrugresearchanddevelopment.Thispaperfocusesonthescreeningofanti-tumoractivesubstancesandtheiranti-tumormechanisms.Inthispaper,weintroducethecriteriaforscreeninganti-tumoractivesubstancesandvariousmethodsforscreening,andsummarizethelatestresearchprogressontheanti-tumormechanismsofsomeactivesubstances.Theanti-tumormechanismsincludeinductionofapoptosis,inhibitionofangiogenesis,regulationofimmunefunctionandsuppressionoftumorcellinvasionandmetastasis.Thestudyofanti-tumoractivesubstancesandtheirmechanismsofactionprovidesatheoreticalbasisfordevelopingnewanti-tumordrugs,andhasapositiveimpactonthepreventionandtreatmentoftumordiseases. Introduction: Cancerisamajorglobalhealthproblemthataffectsmillionsofpeopleeachyear.Currently,chemotherapy,radiotherapyandsurgeryarethemainmethodsusedforthetreatmentofcancer,buttheyareoftenaccompaniedbyseveresideeffectsandarenotalwayseffective.Therefore,thesearchfornewandeffectiveanti-tumordrugshasbecomearesearchhotspot.Thescreeningandresearchofactivesubstanceswithanti-tumoractivitycanprovidenewmaterialsandideasforthedevelopmentofanti-tumordrugs. Criteriaforscreeninganti-tumoractivesubstances: Thescreeningofanti-tumoractivesubstancesisacomprehensiveevaluationprocess,includingscreeningofactiveingredientsfromnaturalproducts,syntheticcompoundsandtraditionalChinesemedicineextracts.Thefollowingarethecriteriaforscreeninganti-tumoractivesubstances: 1.Effectiveinhibitionoftumorcellgrowth:Activesubstancesshouldeffectivelyinhibittumorcellproliferationandreducetumorvolume. 2.Lowtoxicity:Activesubstancesshouldhavelowtoxicityandfewsideeffects. 3.Cellselectivity:Activesubstancesshouldhaveselectivecytotoxicitytotumorcellsandlittleeffectonnormalcells. 4.Watersolubility:Activesubstancesshouldbeeasilydissolvedinwater,whichcanfacilitateoraladministrationorinjection. Methodsforscreeninganti-tumoractivesubsta