预览加载中，请您耐心等待几秒...

复方灵芝红景天制剂对小鼠免疫功能的影响及抗疲劳作用研究.docx

预览
1/3
2/3
3/3

在线预览结束，喜欢就下载吧，查找使用更方便

下载提示 文本预览

如果您无法下载资料，请参考说明：

1、部分资料下载需要金币，请确保您的账户上有足够的金币

2、已购买过的文档，再次下载不重复扣费

3、资料包下载后请先用软件解压，在使用对应软件打开

复方灵芝红景天制剂对小鼠免疫功能的影响及抗疲劳作用研究 Title:TheInfluenceofCompoundLingzhiandHongjingtianPreparationonImmuneFunctionandAnti-FatigueEffectinMice Abstract: TheobjectiveofthisstudywastoinvestigatetheinfluenceofCompoundLingzhiandHongjingtianpreparationonimmunefunctionanditspotentialanti-fatigueeffectinmice.Forty-eighthealthymalemicewererandomlydividedintofourgroups:Controlgroup,Low-dosegroup,Medium-dosegroup,andHigh-dosegroup.ThemiceintheexperimentalgroupswereadministeredwiththeCompoundLingzhiandHongjingtianpreparationdailyforaperiodoffourweeks.Theimmunefunctionwasassessedbymeasuringthelevelsofserumimmunoglobulins(IgG,IgM,andIgA),cytokines(IL-2,IL-6,andTNF-α),andlymphocytesubsets(CD3+,CD4+,CD8+,andCD4+/CD8+ratio).Theanti-fatigueeffectwasevaluatedbyrecordingtheexhaustionandswimmingtimesduringanexhaustiveswimmingtest.TheresultsshowedthattheCompoundLingzhiandHongjingtianpreparationsignificantlyincreasedthelevelsofserumimmunoglobulinsandcytokines,aswellasthepercentagesofCD3+andCD4+lymphocytesubsetsinadose-dependentmanner.Moreover,theswimmingtimetoexhaustionwassignificantlyprolongedinthetreatedgroupscomparedtothecontrolgroup.ThesefindingssuggestthatCompoundLingzhiandHongjingtianpreparationcanenhanceimmunefunctionandexhibitanti-fatigueeffectsinmice. 1.Introduction Immunefunctionplaysacrucialroleinprotectingthebodyfromvariousdiseases.However,factorssuchasstress,aging,andchronicdiseasescanimpairtheimmunesystem,leadingtodecreasedimmunityandincreasedsusceptibilitytoinfections.Therefore,enhancingimmunefunctionisofgreatimportanceformaintaininghealthandpreventingdiseases. Lingzhi(Ganodermalucidum)andHongjingtian(Rhodiolarosea)aretwotraditionalChinesemedicinalherbswithalonghistoryofuseintraditionalmedicine.Lingzhihasbeenreportedtopossessvariouspharmacologicalactivities,includingimmunomodulatoryeffects,antioxidantproperties,andanti-tumoractivities.Hongjingtian,ontheotherhand,isknownforitsadaptogenicandanti-fatigueeffects.BothherbshavebeenwidelyusedintraditionalChinesemedicineformulationsforimpro