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环状RNA翻译能力研究进展.docx

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环状RNA翻译能力研究进展 Title:ResearchProgressonCircularRNATranslationCapacity Abstract: CircularRNAs(circRNAs)areauniqueclassofnon-codingRNAsthatformacovalentlyclosedcircularstructure.Initiallyconsideredasbyproductsofsplicingerrors,circRNAsarenowknowntoplaycriticalrolesingeneregulationandvariousbiologicalprocesses.WhilemostcircRNAshavebeenthoughttolackprotein-codingpotential,recentstudieshaverevealedthatasubsetofcircRNAsiscapableoftranslation,leadingtothegenerationoffunctionalpeptidesorproteins.ThisreviewsummarizesthecurrentknowledgeonthetranslationofcircRNAs,includingthemechanismsinvolvedandthepotentialimplicationsforhumanhealthanddisease.Additionally,challengesandfutureperspectivesincircRNAtranslationresearcharediscussed. 1.Introduction: 1.1DefinitionandcharacteristicsofcircRNAs 1.2FunctionofcircRNAsingeneregulation 1.3EmergingconceptofcircRNAtranslationcapacity 2.MechanismsofcircRNAtranslation: 2.1Cap-independenttranslationinitiation 2.2Internalribosomeentrysites(IRES) 2.3N6-methyladenosine(m6A)modification 2.4Otherpotentialtranslationmechanisms 3.EvidencesupportingcircRNAtranslation: 3.1ExperimentaltechniquestodetectcircRNAtranslation 3.2IdentifiedfunctionalpeptidesandproteinstranslatedfromcircRNAs 3.3RegulatoryrolesofcircRNA-translatedproducts 4.ImplicationsofcircRNAtranslationinhumanhealthanddisease: 4.1Cancerdevelopmentandprogression 4.2Neurologicaldisorders 4.3Cardiovasculardiseases 4.4Otherphysiologicalandpathologicalconditions 5.Challengesandfutureperspectives: 5.1ReliabledetectionandquantificationofcircRNAtranslation 5.2FunctionalcharacterizationofcircRNA-translatedproducts 5.3Developmentofexperimentalmodelsandtools 5.4TherapeuticpotentialofcircRNAtranslation 6.Conclusion Keywords:circularRNA,translation,cap-independent,internalribosomeentrysites,m6Amodification,cancer,neurologicaldisorders,cardiovasculardiseases,therapeutics. Introduction: CircularRNAs(circRNAs),afamilyofcovalentlyclosedRNAmolecules,wereinitiallyregardedasbyproductsofsplicingerrors.However,recent