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甲状腺及抗甲状腺素药ppt课件.ppt

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甲状腺激素和抗甲状腺药Thetwomajorthyroidhormonesarethriiodothyronine(T3)andthyroxine(T4).Theyareessentialfornormalgrowthanddevelopmentandplayanimportantroleinenergymetabolism. Thepredominantactionsofthyroidhormonesaremediatedbybindingtonuclearthyroidhormonereceptorsandmodulatingtranscriptionofspecificgenes. Antithyroiddrugsconsistofthioureas,iodide,radioiodine(131I)andβ-adrenoceptorantagonist. Thioureasinhibitthesynthesisofthyroidhormones.PropythiouracilcanalsoblocktheconversionofT4toT3inperipheraltissues.Highconcentrationsofiodideappeartoinfluencealmostallimportantaspectsofiodidemetabolismbythethyroidgland,especiallyincludinganinhibitionofthereleaseofthyroidhormones. 131Iexertsadestructionofthyroidglandbybetaparticles. Themajorindicationsforthetherapeuticuseofthyroidhormonesareforhormonereplacementtherapyinpatientswithhypothyroidismorcretinism,andantithyroiddrugsareforthetreatmentofhyperthyroidindividual.学习目的与要求anteriorpituitary硫脲类—【作用机制】硫脲类—不良反应