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胃癌中SPIN1的异常表达及作用机制研究.docx

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胃癌中SPIN1的异常表达及作用机制研究 Title:AberrantExpressionandMechanismsofSPIN1inGastricCancer Abstract: Gastriccancerremainsoneoftheleadingcausesofcancer-relatedmortalityworldwide.Theidentificationofnovelbiomarkersandtherapeutictargetsiscrucialforimprovingthediagnosisandtreatmentofgastriccancer.SPIN1,alsoknownasSpindlin1,isamultifunctionalproteinthathasbeenreportedtoplayaroleinvariouscancers,includinggastriccancer.ThisreviewfocusesontheabnormalexpressionandfunctionalmechanismsofSPIN1ingastriccancer. Introduction: Gastriccancerisamajorpublichealthconcern,accountingforasignificantnumberofcancer-relateddeathsglobally.Despiteadvancementsinthediagnosisandtreatmentofthisdisease,theoverallsurvivalrateforgastriccancerpatientsremainslow.Therefore,understandingthemolecularmechanismsunderlyinggastriccancerdevelopmentandprogressioniscriticalforthedevelopmentofeffectivetargetedtherapies.SPIN1hasemergedasapotentialbiomarkerandtherapeutictargetforgastriccancerduetoitsaberrantexpressionanddiversefunctions. AberrantExpressionofSPIN1inGastricCancer: PreviousstudieshavereportedthatSPIN1isfrequentlyoverexpressedingastriccancertissuecomparedtonormalgastrictissue.ElevatedSPIN1expressionhasbeenassociatedwithtumorsize,lymphnodemetastasis,andpoorprognosisingastriccancerpatients.Additionally,SPIN1expressionispositivelycorrelatedwithvariousclinicopathologicalparameters,includingtumorstage,invasiondepth,anddistantmetastasis.ThesefindingssuggestthatSPIN1mayserveasapotentialbiomarkerformonitoringtumorprogressionandpredictingpatientprognosisingastriccancer. FunctionalMechanismsofSPIN1inGastricCancer: ThefunctionalroleofSPIN1ingastriccancerhasbeenextensivelyinvestigated.SPIN1promotestumorcellproliferation,migration,invasion,andepithelial-mesenchymaltransition(EMT)throughtheregulationofmultiplesignalingpathways.SPIN1interactswithvarioustranscriptionfactors,suchasβ-catenin,p53,andestrogenreceptorα,tomodulatedownstreamtargetgenesinvolvedincellcycleprogression,apoptosis,andEMT.Additionally,SPIN1hasbeenshowntoenhan