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鸡血-脾屏障及其淋巴细胞归巢的机制研究 Title:TheMechanismsofChickenSplenicBarrierandtheHomingofLymphocytes Abstract: Thespleenisavitalorganinvolvedinimmuneresponseandhematopoiesis.Itplaysacrucialroleinfilteringbloodpathogens,controllingtheimmuneresponse,andgeneratinganadequateimmuneresponseagainstinfections.Thispaperaimstoexplorethemechanismofthechickensplenicbarrierandthehomingoflymphocytes.Theresearchshedslightonunderstandingthecomplexitiesoftheimmunesystemandpotentiallypavethewayfornewtherapeuticstrategiesinpoultryhealth. 1.Introduction: 1.1Background: Thespleenisasecondarylymphoidorganlocatedintheabdominalcavityandactsasacentralhubforregulatingimmuneresponsesinpoultry.Understandingthesplenicbarrierandlymphocytehomingmechanismsisessentialforcomprehendingtheimmuneactivityinchickens. 2.StructureandFunctionoftheChickenSpleen: 2.1AnatomyoftheChickenSpleen: Thechickenspleenconsistsoftwomainregions:theredpulpandthewhitepulp.Theredpulpisinvolvedinbloodfiltration,whilethewhitepulpisresponsibleforimmuneactivitiesandlymphocytetrafficking. 2.2ImmuneFunctionsoftheSpleen: Thespleenperformsvariousimmunefunctions,includingantigenrecognition,immunecellactivation,antibodyproduction,andclearanceofpathogens.Itservesasareservoirforbloodmonocytes,erythrocytes,andlymphocytes. 3.SplenicBarrierMechanisms: 3.1CellularComponentsoftheSplenicBarrier: Thesplenicbarrierprimarilycomprisesendothelialcells,macrophages,anddendriticcells.Thesecellscooperatetomonitortheentryofantigensandregulatetheimmuneresponse. 3.2RoleofEndothelialCellsandFenestrations: Endothelialcellsliningthesplenicvasculaturefacilitatethefiltrationofbloodborneantigens.Fenestrations,smallgapsbetweentheendothelialcells,allowtheentryofantigensintotheredpulpforimmunesurveillance. 3.3MacrophagesandDendriticCellsintheRedPulp: Macrophagesanddendriticcellsinthesplenicredpulpcaptureandprocessantigensforpresentationtolymphocytes.Theyplayacrucialroleininitiatingimmuneresponses. 4.LymphocyteHomingMechanismsintheSpleen: 4.1LymphocyteMigrationandRecirculatio