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PiCCO容量监护仪在ICU中的应用Centralvenouscatheter •jugular •subclavian •femoralCentralvenouscatheter •jugular •subclavian •femoralPiCCO技术可以监测心输出量TranspulmonarythermodilutionmethodTranspulmonarythermodilution COmeasurement (vsPAthermodilution)PCCO=cal.HR.(P(t)/SVR+C(p).dP/dt)dtValidationofcontinuouscardiacoutputmeasurementbythe pulsecontouranalysis(PiCCOsystem) PiCCO所得连续心排量数值准确性论证 目前医学界判斷心脏前負荷的标准RaperRandSibbaldWJ.Chest1986 Misledbythewedge?TheSwan-Ganzcatheterandleftventricularpreload.GEDV可以作为心脏前负荷的指标COxMTt=volumeofdistribution=1+2+3+4+5COxMTt=volumeofdistribution=1+2+3+4+5COxMTt=volumeofdistribution=GEDV+PBV+EVLWChangesin strokevolume index(%)治疗指南-SurvivingSepsisCampaignGuidelines2008: »灌注压在评估扩容治疗中已经被证实有局限性...使用血流量或者容量参数指导容量管理或许更有优势…这些技术已经能够在ICU内实现…«Intrathoracicpressure Venousreturntoleftandrightventricle Leftventricularpreload Leftventricularstrokevolume SystolicarterialbloodpressureSVV反映了心脏对因机械通气导致的前负荷周期性变化的敏感性。1,15,18,19,20 SVV可用于预测扩容治疗对每搏量的提高程度。1,15,18,19,20心肌收缩状况TEEFACPiCCO心肌收缩力参数全心射血分数(GEF) (经肺热稀释导管)COxMTtcold=coldindicatorvolumeofdistribution46Source Comparison Correlation Baudendisteletal,1982,JTrauma22:983 X-rayscorevs.EVLW* 77% Sibbaldetal,1983,Chest83:725 comparisoncardiacedema r=0,66 comparisonnoncardiacedema r=0,7 Sivaketal,1983,CritCareMed.11:498 X-rayscorevsEVLW* 64% X-rayscorevs.EVLW* 42% Laggneretal,1984,IntensiveCareMed.10:309 X-rayscorevs.EVLW* r=0,84 no/low/highPE,estimatedbyradiologists Halperinetal,1985,Chest88:649 X-rayscorevs.EVLW* r=0,51 Halleretal,1985,Fortschr.Röntgenstr.142:68 X-rayscorevs.EVLW* 66% Eisenbergetal,1987,AmRevRespDis136:662 X-rayscorevs.EVLW* 76% Takedaetal,1995,JVetMedSci57(3):481 X-rayscorevs.EVLW* X-rayinsensitive 373位重症ICU病人中EVLWI与死亡率的关系:其中193人感染,49人ARDS,48人头部创伤,83人出血性休克。 根据EVLW的数值病人分成四组。 Sakkaetal,Chest2002利用EVLW治疗病人Incriticallyillpatientsforidentifyingpatientswithpulmonaryedema 针对危重病人,甄别病人是否有肺水肿Incriticallyillpatients foridentifyingpatientswithpulmonaryedema 针对危重病人,甄别病人是否有肺水肿PiCCO肺相关指标Incriticallyi