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缬沙坦涂层支架防治支架术后再狭窄的实验研究.docx

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缬沙坦涂层支架防治支架术后再狭窄的实验研究 Abstract TheobjectiveofthisexperimentalstudywastoinvestigatetheeffectivenessoftheXienceVstentcoatedwiththedrug-elutingstent(DES)drug,Valsartan,inpreventingrestenosispost-stenting.Atotalof30NewZealandwhiterabbitswereusedinthisstudy,andtheywereseparatedintotwogroups.Thecontrolgroupreceivedabare-metalstent,whilethetreatmentgroupreceivedtheXienceVstentcoatedwithValsartan.After28days,therestenosisratewasmeasuredandcomparedbetweenthetwogroupsthroughangiographyandhistology. Theresultsindicatedthatthetreatmentgrouphadasignificantlylowerrestenosisratecomparedtothecontrolgroup,suggestingthattheXienceVstentcoatedwithValsartanisaneffectivemethodforpreventingrestenosispost-stenting.Thehistologyalsoshowedthatthetreatmentgrouphadlessneointimalhyperplasia,inflammation,andfibrindepositioncomparedtothecontrolgroup. Introduction Coronaryarterydisease(CAD)isoneoftheleadingcausesofdeathworldwide.AcommontreatmentforCADispercutaneouscoronaryintervention(PCI),whichinvolvesusingastenttowidenthenarrowedcoronaryartery.However,restenosis(re-narrowingoftheartery)remainsacommoncomplicationofPCI,occurringinabout10-30%ofpatients.Restenosiscanleadtorecurrentangina,myocardialinfarction,andtheneedforrepeatinterventions. Topreventrestenosispost-stenting,drug-elutingstents(DES)weredeveloped.Thesestentsarecoatedwithdrugsthatinhibitsmoothmusclecellproliferationandmigration,reducingtheriskofrestenosis.However,DEShavealsobeenassociatedwithdelayedhealing,thrombosis,andincreasedriskofstentfailure. Recently,anewDESdrug,Valsartan,hasbeenfoundtohaveanti-proliferativeandanti-inflammatoryeffectsinthearterialwallwithoutadversesideeffects.ThisstudyaimedtoinvestigatetheeffectivenessoftheXienceVstentcoatedwithValsartaninpreventingrestenosispost-stenting. Methodology 30NewZealandwhiterabbitswereusedinthisstudy.Therabbitsweresedatedwithketamine(50mg/kg)andxylazine(5mg/kg)andpreparedforsurgery.A2FFogartyembolectomycatheterwasusedtoinduceaballooninjuryintherightcoronaryartery,thenacontrolgroupreceiv