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生物材料特性及微环境对间充质干细胞向心肌细胞分化的作用研究.docx

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生物材料特性及微环境对间充质干细胞向心肌细胞分化的作用研究 Title:TheRoleofBiomaterialPropertiesandMicroenvironmentinDirectingMesenchymalStemCellDifferentiationtowardsCardiomyocytes Abstract: Cardiovasculardiseasesremainasignificantcauseofmorbidityandmortalityworldwide.Regenerativetherapyutilizingmesenchymalstemcells(MSCs)holdsgreatpromiseforcardiactissuerepairandregeneration.However,directingthedifferentiationofMSCsintofunctionalcardiomyocytesremainsachallenge.ThisreviewpaperaimstoexploretheinfluenceofbiomaterialpropertiesandthesurroundingmicroenvironmentonpromotingMSCdifferentiationintocardiomyocytes.Acomprehensiveunderstandingofthesefactorscanprovidevaluableinsightstoenhancetheeffectivenessofregenerativestrategiesforcardiactissuerepair. 1.Introduction: Cardiovasculardiseasesarealeadingcauseofdeathglobally.Thelimitedregenerativecapacityoftheadultheartnecessitatesnewtherapeuticapproachesforcardiactissuerepair.Mesenchymalstemcells(MSCs),withtheirregenerativepotential,haveemergedasapromisingcellsourceforcardiacregeneration.However,theirdifferentiationintomatureandfunctionalcardiomyocytesremainsasignificanthurdle.ThefocusofthisstudyistoexploretheroleofbiomaterialpropertiesandthemicroenvironmentinguidingMSCdifferentiationtowardscardiomyocytes. 2.BiomaterialProperties: 2.1ScaffoldArchitecture: ThearchitectureofthebiomaterialscaffoldplaysacrucialroleindirectingMSClineagecommitment.Topographicalcues,suchasnanofibersormicropatterns,havebeenshowntopromotecardiomyocytedifferentiation.ThesubstratestiffnesscanalsoinfluenceMSCfate,withsoftersubstratespromotingcardiac-specificgeneexpression.Furthermore,theincorporationofgrowthfactors,extracellularmatrixproteins,andbioactivemoleculeswithinthescaffoldcanenhancecardiomyogenicdifferentiation. 2.2MechanicalProperties: Themechanicalpropertiesofbiomaterials,suchasstiffnessandelasticity,canaffectMSCbehaviorandcommitmenttothecardiaclineage.Abiomaterialwithoptimalmechanicalpropertiesmimickingnativemyocardiumcanprovidethenecessaryphysicalcuesforcardiomyocytedifferentia