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川芎嗪对单侧输尿管梗阻大鼠肾间质炎症反应及纤维化的影响.docx

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川芎嗪对单侧输尿管梗阻大鼠肾间质炎症反应及纤维化的影响 Abstract： Objective:ToinvestigatetheeffectofChuanxiongqinontheinflammationandfibrosisofrenalinterstitiuminratswithunilateralureteralobstruction. Methods:FortyhealthymaleSDratswererandomlydividedintofourgroups:shamoperationgroup,modelgroup,andChuanxiongqinlowandhighgroups.Aftersuccessfulmodelingofunilateralureteralobstructioninrats,theratsintheChuanxiongqinlowandhighgroupsweregivenChuanxiongqinatdifferentdoseaccordingtotheweightofratsfor4weeks.Allratsweresacrificedattheendoftheexperiment,andthetissuesofthekidneywerecollectedforpathologicaldetection,HEstaining,Massonstaining,anddetectionofthelevelsofinflammatoryfactors. Results:Thehigh-doseChuanxiongqingroupshowedasignificantreductionintheinfiltrationofinflammatorycellsintherenalinterstitium,andthelevelsofIL-6,IL-1βandTNF-αweresignificantlylowerthanthoseinthemodelgroup(P<0.05);Inaddition,therenalinterstitialfibrosisscorewassignificantlylowerthanthatinthemodelgroup(P<0.05).Thelow-dosegroupalsoshowedatrendofreductionininflammationandfibrosis,buttheeffectwasnotasobviousasthehigh-dosegroup. Conclusion:Chuanxiongqinhasacertainprotectiveeffectontheinflammationandfibrosisofrenalinterstitiuminratswithunilateralureteralobstruction,andtheeffectisdose-dependent. Keywords:Chuanxiongqin,inflammation,fibrosis,renalinterstitium,unilateralureteralobstruction. Introduction: Renalinterstitialfibrosis(RIF)isapathologicalprocessofthedevelopmentofmanychronickidneydiseases(CKD)involvedinthelossofkidneyfunction.ObstructivenephropathyisanimportantfactorleadingtoCKD,inwhichunilateralureteralobstruction(UUO)isacommonclinicaldiseasethatleadstokidneyinterstitialfibrosis. Chuanxiongqin（川芎嗪）,asaconventionalChinesemedicine（TCM）,hasbeenusedtotreatmanydiseases,suchashypertension,cardiovasculardiseases,andcerebrovasculardiseases.InvivoandinvitrostudieshaveshownthatChuanxiongqinhasavarietyofpharmacologicalactivities,includinganti-inflammatory,anti-oxidant,antithrombotic,andanti-stress.However,studiesontheeffectofChuanxiongqi