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基于高通量测序研究陈皮提取物对高脂饮食小鼠肠道菌群的影响.docx

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基于高通量测序研究陈皮提取物对高脂饮食小鼠肠道菌群的影响 Title:EffectsofChenpiExtractontheGutMicrobiotaofHigh-FatDiet-inducedMice:InsightsfromHigh-ThroughputSequencing Abstract: Thegutmicrobiotahasemergedasavitalcomponentofhumanhealth,affectingvariousphysiologicalfunctions.Inrecentyears,therehasbeengrowinginterestinstudyingtheimpactofnaturalproductsongutmicrobiota.ThisstudyaimedtoinvestigatetheeffectsofChenpiextract,atraditionalChinesemedicinederivedfromthedriedcitruspeel,onthegutmicrobiotacompositionofmicefedahigh-fatdiet.High-throughputsequencingwasemployedtocharacterizethechangesinthegutmicrobiotafollowingChenpiextractadministration.OurfindingssuggestthatChenpiextractsupplementationcanpotentiallymodifythegutmicrobiotaandimproveimbalancesassociatedwithhigh-fatdiet-induceddysbiosis. Keywords:Chenpiextract,gutmicrobiota,high-throughputsequencing,dysbiosis,high-fatdiet Introduction: Thegutmicrobiotaisacomplexecosystemconsistingoftrillionsofmicroorganisms,residinginthegastrointestinaltractofhumansandanimals.Itplaysasignificantroleinvariousphysiologicalprocesses,includingnutrientmetabolism,immunefunction,andgutbarrierintegrity.Dysbiosis,animbalanceinthecompositionandfunctionofthegutmicrobiota,hasbeenlinkedtovariousmetabolicdisorders,includingobesityandtype2diabetes.Dietaryinterventionsfocusingonmodulatingthegutmicrobiotahavegainedconsiderableattentionasapotentialstrategyforimprovingmetabolichealth.TraditionalChinesemedicine,withitslonghistoryandrichherbalresources,offersapromisingavenueforidentifyingnaturalproductsthatmaypositivelyimpactgutmicrobiotacomposition. Chenpi,derivedfromthedriedpeelofcitrusfruits,hasbeenusedasatraditionalChineseherbalmedicineforcenturiestotreatvariousdigestivedisorders.Itcontainsavarietyofbioactivecompounds,includingflavonoids,coumarins,andvolatileoils,whichpossesspotentantioxidantandanti-inflammatoryproperties.Thesebioactivecompoundshavethepotentialtomodulatethegutmicrobiotacompositionandmetabolicpathways,consequentlyleadingtoimprovedmetabolichealth. Methods: Inthisstu