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海藻酸钠水凝胶的制备及其在药物控释中的应用概况控释制剂指药物能在预定的时间内自动以预定的速度释放,使血药浓度长时间恒定维持在有效浓度范围之内的制剂。水凝胶简介海藻酸钠(NaAlg)的构造与性质海藻酸钠(NaAlg)水凝胶作为药物控释剂的理由+H+戊二醛、环氧氯丙烷海藻酸钠水凝胶在药物释放中的应用Fig.2ImagesofF2andF5tabletsduringtheirswellingfor24h.口服给药——肠部Fig.4Pentoxifyllineplasmac-tcurvefollowingoraladministrationofF2andareferencesolutioninrats.口服给药——肠道Fig.2Swellingdegreesofalginate/κ-carrageenancompositebeadsformedat0(),0.1(),and1(×)%w/vofκ-carrageenanconcentrationin(a)water,(b)SGFatpH1.2,and(c)SIFatpH7.4.Fig.3Invitroreleaseofinsulinaspartfromthealginate/κ-carrageenancompositehydrogelbeadsformedatdifferentκ-carrageenanconcentrations(in%w/v)in(a)SGFatpH1.2and(b)SIFatpH7.4,at37oC.皮下给药肺部给药Chem.Eng.J.357()559–566Fig.1(a)SEMimageofthealginateaerogelmicrospheres. (b)SEMimageofthesurfaceofalginateaerogelparticlesloadedwith3wt%ofsalbutamolsulphate.Inset:highermagnificationof thesurfaceshowingafractionofthedrugintheformof needle-likecrystals. Fig.2InvitroreleaseprofileofSSfromalginateaerogelmicropheres(whitecircles)inPBSpH7.4solution.ThedissolutionprofileofSS(blacksquares)underthesameoperatingconditionsisplottedforcomparison.总结Thanksforyourattention!