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一种新的抗流感病毒鸡胚模型的建立.docx

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一种新的抗流感病毒鸡胚模型的建立 Abstract Withtheoutbreakofinfluenzavirus,theestablishmentofanewanti-influenzaviruschickenembryomodelisanurgentneed.Thepresentstudyaimedtobuildsuchamodelandevaluateitsvalidity.Inthisresearch,chickenembryoswereutilizedasanewmodeltoevaluatetheantiviraleffectsofagentsagainstinfluenzavirus,includingH1N1andH3N2.Resultsshowedthatthechickenembryomodelisnotonlyeffectiveandusefulfortestingtheanti-viralefficacyofdrugsbutalsocost-effectiveandtime-saving.Inconclusion,theestablishedchickenembryomodelisapromisingalternativeforstudyingthepathogenesisofinfluenzavirusandevaluatingtheantiviraleffectsofnewagents,providinganewtoolforinfluenzaresearch. Keywords:influenzavirus,chickenembryomodel,antiviraleffects,H1N1,H3N2. Introduction Influenzavirusisanextremelycontagiousrespiratoryinfectionthatcausesamassiveglobalimpact[1].Itspreadsveryquicklyinschools,hospitals,homes,andoffices,resultinginsignificantmorbidityandmortalityinpeopleofallages,especiallychildren,elderly,andindividualswithexistingcomorbidities[2].Influenzavirusepidemicsarecausedbyrapidmutationofviralantigens,resultinginanunpredictableviralmorphologythatisalmostimpossibletoanticipate[3].Despitetheavailabilityofseverallicensedvaccinesandanti-influenzaagentsworldwide,influenzaviruscontinuestoposeasignificantpublichealthburdenintheworld. Antiviraltreatmentandprophylaxiswithanti-influenzaagentsaretypicallyusedtoreducetheseveremorbidityandmortalitycausedbyinfluenzavirus.However,itisnecessarytoidentifyeffectiveandsafeanti-influenzaagentstocombatthechallengesposedbyinfluenzavirus[4].Currently,theeffectivenessofanti-influenzaagentsistypicallyevaluatedusinginvitrocellcultureoranimalmodels,suchasferrets,mice,andguineapigs.However,thesemodelshavesomelimitations,suchasthetime-consumingandexpensivenatureofinvivomodelsandthepoorreproducibilityandhighvariabilityofinvitromodels.Consequently,thereisaneedforanimprovedanimalmodelofthediseasewithenhancedefficacy,reproducibility,andconvenience. Chickenembryosofferanalternativeands