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RAFT光分散聚合制备单分散聚合物微球的研究 Title:RAFT光分散聚合制备单分散聚合物微球的研究 Abstract: Theproductionofmonodispersepolymermicrosphereshasattractedsignificantattentionduetotheirwidespreadapplicationsinvariousfields,includingdrugdelivery,diagnostics,andmaterialsscience.Inthisstudy,weinvestigatethesynthesisofmonodispersepolymermicrospheresusingareversibleaddition-fragmentationchaintransfer(RAFT)photodispersionmethod.Thisapproachoffersprecisecontroloverthesizeandmorphologyofthemicrospheres,facilitatingtheirapplicationsinnanotechnologyandbiomedicine.Thispaperhighlightsthesignificantadvances,challenges,andfutureprospectsofRAFTphotodispersionpolymerizationforthesynthesisofmonodispersepolymermicrospheres. Introduction: Monodispersepolymermicrosphereshaveemergedasversatilebuildingblockswithwide-rangingapplicationsindrugdelivery,biosensors,tissueengineering,andcatalystsupports.Thecontrolofsize,shape,andsurfacefunctionalitiesofthesemicrospheresiscrucialtooptimizetheirperformanceinvariousapplications.TheRAFTphotodispersionmethodprovidesapromisingapproachfortheprecisesynthesisofmonodispersepolymermicrospheres. Methodology: 1.PhotodispersionTechnique: TheRAFTphotodispersiontechniqueutilizesalight-activatedinitiatorforthecontrolledandrapidgenerationofstablemacroradicals,allowingtheinsituformationofmonomersaroundtheseradicals. 2.RAFTPolymerization: ThemacroradicalsinitiatethecontrolledRAFTpolymerization,leadingtotheformationofwell-definedpolymerchains. 3.ParticleFormation: Thepolymerchainsself-assembletoformmonodispersepolymermicrosphereswithcontrolledsizeandmorphology. ResultsandDiscussion: 1.RAFTPhotodispersion:AnOverview TheadvantagesofRAFTphotodispersionovertraditionalpolymerizationmethodsincludehighcontroloversizedistribution,tunableparticleproperties,andtheabilitytoincorporatevariousfunctionalgroups. 2.InfluenceofReactionParameters Thesizeanddistributionofpolymermicrospherescanbetunedbycontrollingreactionparameterssuchasmonomerconcentration,lightintensity,andreactiontime. 3.SurfaceModificationandFunct