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6：2氯代氧杂氟烷磺酸钾(F-53B)对小鼠肝脏及生殖毒性的研究.docx

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6：2氯代氧杂氟烷磺酸钾(F-53B)对小鼠肝脏及生殖毒性的研究 Title:TheHepaticandReproductiveToxicityof6:2ChlorinatedOxygenatedHeterofluorocarbonPotassiumSulfonicAcid(F-53B)inMice Abstract: Theaimofthisstudywastoinvestigatethehepaticandreproductivetoxicityof6:2chlorinatedoxygenatedheterofluorocarbonpotassiumsulfonicacid(F-53B)inmice.ThemicewereexposedtodifferentdosesofF-53B,andtheirhepaticfunctionandreproductiveparameterswereassessed.TheresultsshowedthatF-53Bexposureledtoliverdamageandreproductivedysfunctioninmice,suggestingitspotentialhazardtohumanhealth. Introduction: Theusageof6:2chlorinatedoxygenatedheterofluorocarbonpotassiumsulfonicacid(F-53B)hasbeenincreasinginrecentyearsduetoitsindustrialapplications.However,littleisknownaboutitspotentialtoxiceffectsonorganisms,particularlyontheliverandreproductivesystem.Hence,thisstudyaimedtoevaluatethehepaticandreproductivetoxicityofF-53Binmice. Methods: 1.Animalgrouping:MaleandfemalemicewererandomlydividedintocontrolandF-53Bexposuregroups. 2.F-53Bexposure:MiceintheexposuregroupswereadministereddifferentdosesofF-53Bthroughintraperitonealinjectionororalgavageforaspecifiedduration. 3.Hepaticfunctionassessment: a.Measurementofliverenzymes:Serumalanineaminotransferase(ALT)andaspartateaminotransferase(AST)levelsweredetermined. b.Histopathologicalexamination:Livertissueswereprocessedforhistologicalanalysisusinghematoxylinandeosinstaining. 4.Reproductiveassessment: a.Estrouscyclemonitoring:Vaginalsmearswerecollectedandanalyzedtoassesstheestrouscycle. b.Attheendofexposure,thereproductiveorganswerecollected,weighed,andexaminedhistologically. c.Spermanalysis:Spermcount,motility,andmorphologywereevaluatedinmalemice. 5.Statisticalanalysis:Datawereanalyzedusingappropriatestatisticalmethods,andp-valueslessthan0.05wereconsideredstatisticallysignificant. Results: 1.Hepaticfunctionassessment: a.SerumALTandASTlevelsweresignificantlyelevatedinF-53B-exposedmicecomparedtocontrols(p<0.05). b.Histopathologicalexaminationexhibitedlivertissuedamage,includinghepatocytenecrosis