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黄芪甲苷对镉致大鼠睾丸支持细胞损伤的保护作用.docx

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黄芪甲苷对镉致大鼠睾丸支持细胞损伤的保护作用 摘要 该研究旨在探究黄芪甲苷对镉致大鼠睾丸支持细胞损伤的保护作用。本研究采用镉处理大鼠模型，使用黄芪甲苷作为试剂保护作用的一项，并比较不同剂量的保护作用。结果表明，黄芪甲苷可以显著减少镉的影响，并且对于损伤的修复有显著的促进作用。进一步分析结果发现，黄芪甲苷可以通过抑制氧化应激和细胞凋亡来减少镉对睾丸支持细胞的损伤。因此，黄芪甲苷在保护睾丸的健康方面具有潜在的应用关键词：黄芪甲苷；镉；睾丸支持细胞；氧化应激；细胞凋亡 Abstract ThisstudyaimedtoinvestigatetheprotectiveeffectofAstragalosideIVoncadmium-induceddamagetorattesticularSertolicells.Thecadmium-treatedratmodelwasusedinthestudy,andAstragalosideIVwasusedasareagenttoprotectagainstdamage,comparingtheprotectiveeffectsofdifferentdoses.TheresultsshowedthatAstragalosideIVcouldsignificantlyreducetheimpactofcadmiumandhadasignificantpromotingeffectontherepairofdamage.FurtheranalysisfoundthatAstragalosideIVcanreducethedamageofcadmiumtoSertolicellsbyinhibitingoxidativestressandcellapoptosis.Therefore,AstragalosideIVhaspotentialapplicationinprotectingthehealthoftestes. Keywords:AstragalosideIV;Cadmium;TesticularSertolicells;Oxidativestress;Cellapoptosis Introduction Cadmium,aheavymetal,hasbeenwidelyusedinindustrialproductionandhascausedseriouscontaminationoftheenvironment.Cadmiumcanbeabsorbedbythebodythroughvariouschannelssuchasfood,water,andair,andithasbeenreportedtocausedamagetovariousorgansofthebody,includingthereproductivesystem(Nairetal.,2014).Thetestesplayanimportantroleinmalereproduction,anddamagetotesticularSertolicellscanleadtomaleinfertility(Negietal.,2019).Therefore,itisessentialtodevelopeffectivemeasurestoprotectthetesticularfunctionofmenexposedtocadmium. AstragalosideIV,anaturalproductextractedfromtherootoftheChinesemedicinalherbAstragalusmembranaceus,hasbeenreportedtohaveantioxidant,anti-inflammatory,andanti-apoptoticeffects(Zhaoetal.,2019).StudieshaveshownthatAstragalosideIVhasaprotectiveeffectonthereproductivesystem,suchastheovaryandthetestes(Zhaoetal.,2019;Chengetal.,2015).However,whetherAstragalosideIVcanprotectagainstthedamagetoSertolicellscausedbycadmiumisstillunknown. Therefore,inthisstudy,weaimedtoinvestigatetheprotectiveeffectofAstragalosideIVoncadmium-induceddamagetorattesticularSertol