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羟基磷灰石-钛酸钙复合涂层的生物相容性及动物实验研究.docx

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羟基磷灰石-钛酸钙复合涂层的生物相容性及动物实验研究 Abstract Inrecentyears,hydroxyapatite(HA)-titaniumdioxide(TiO2)compositecoatingshavebeenwidelystudiedfortheirpotentialapplicationsinbonetissueengineeringduetotheirexcellentbiocompatibilityandosteoinductivity.ThisstudyaimedtoinvestigatethebiocompatibilityandanimalexperimentsofHA-TiO2compositecoatings.TheresultsshowedthattheHA-TiO2compositecoatingexhibitedgoodbiocompatibilityandcouldpromotethegrowthanddifferentiationofosteoblastsinvitro.InvivoexperimentsusingratsshowedthattheHA-TiO2compositecoatingdidnotcauseanyadversereactionsortoxicity,anditcouldeffectivelypromoteboneformationandosseointegration.ThesefindingssuggestthattheHA-TiO2compositecoatinghasgreatpotentialasabiomaterialforbonetissueengineering. Introduction Bonetissueengineeringisanemergingfieldthataimstoregenerateorrepairbonedefectsorinjuriesusingbiomaterials,cells,andgrowthfactors.Despiterecentadvancesinthisfield,achievingadequateboneregenerationremainsachallenge.Hydroxyapatite(HA)andtitaniumdioxide(TiO2)aretwocommonlyusedbiomaterialsforbonetissueengineering.HAisanaturalcomponentofboneandhasexcellentbiocompatibility,osteoconduction,andosteoinductionproperties.TiO2,ontheotherhand,hasgoodmechanicalstrength,corrosionresistance,andbioactivity.HA-TiO2compositecoatingshavebeenextensivelystudiedaspotentialbonetissueengineeringmaterialsduetotheircombinedadvantagesofbothmaterials. Inthisstudy,weinvestigatedthebiocompatibilityandanimalexperimentsofHA-TiO2compositecoatings.TheaimofthisstudywastoevaluatethefeasibilityofusingHA-TiO2compositecoatingsasabiomaterialforbonetissueengineering. MaterialsandMethods SynthesisofHA-TiO2compositecoating TheHA-TiO2compositecoatingwaspreparedusingasol-gelmethod.Briefly,calciumnitrateandammoniumhydrogenphosphateweredissolvedindeionizedwatertoprepareacalciumphosphatesolution.Titaniumisopropoxidewasthenaddedtothesolution,followedbystirringfor12hourstoobtainahomogenousmixture.Themixturewasthencoatedonatitaniumsubstrateusingaspin-coatingmethodandsinteredat600°Cfo