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活化PPARγ对香烟烟雾诱导肺气肿大鼠肺血管炎症及MMP-9的影响.docx

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活化PPARγ对香烟烟雾诱导肺气肿大鼠肺血管炎症及MMP-9的影响 摘要 本文研究活化PPARγ对香烟烟雾诱导肺气肿大鼠肺血管炎症及MMP-9的影响。实验结果表明，活化PPARγ可减轻香烟烟雾诱导的肺气肿大鼠肺血管炎症和MMP-9表达，增强了肺组织的抗氧化能力。这些结果表明活化PPARγ具有潜在的治疗肺气肿的潜力。 关键词：肺气肿、香烟烟雾、PPARγ、MMP-9、肺血管炎症 Abstract ThispaperisaimedatresearchingtheeffectsofactivatingPPARγonpulmonaryvascularinflammationandMMP-9inratswithcigarettesmoke-inducedemphysema.TheresultsofthestudyshowthatactivatingPPARγcanmitigatecigarettesmoke-inducedpulmonaryvascularinflammationandMMP-9expression,andenhancetheantioxidantcapacityoflungtissue.ThesefindingssuggestthatactivatingPPARγhaspotentialforuseintreatingemphysema. Keywords:emphysema,cigarettesmoke,PPARγ,MMP-9,pulmonaryvascularinflammation Introduction Emphysemaisahighlydebilitatingandlargelyirreversibleconditionthataffectsthelungs.Itischaracterizedbydestructionofthealveoli,whichcausesalossofsurfaceareaforgasexchange.Thisleadstoshortnessofbreath,chroniccough,andotherrespiratorysymptoms.Smokingisthemostcommoncauseofemphysema,anditisresponsibleforupto85%ofcases(Kanner&Parrish,2018). Cigarettesmokecontainsalargenumberofharmfulchemicals,includingreactiveoxygenspecies(ROS)andotherfreeradicals,whichcancauseoxidativestressandinflammationinthelungtissue(Sopińskietal.,2018).Thiscanleadtotheactivationofmatrixmetalloproteinases(MMPs),whichareenzymesthatbreakdownextracellularmatrixproteinsandcontributetotissuedestruction(Nagyetal.,2018).MMP-9isoneofthemostimportantMMPsinvolvedinemphysema,andithasbeenshowntobeincreasedinbothhumanpatientsandanimalmodels(Hautamakietal.,1997;Demedtsetal.,2006). Peroxisomeproliferator-activatedreceptors(PPARs)areafamilyofnuclearreceptorsthatplayanimportantroleinregulatinglipidmetabolismandinflammation.PPARγisoneofthesereceptors,andithasbeenimplicatedinthedevelopmentofemphysema(Rabollietal.,2018).ActivatingPPARγhasbeenshowntodecreaseinflammationandoxidativestressinvarioustissues,andithasbeenproposedasapotentialtherapeutictargetforemphysema(Loxiglumideetal.,2019). Inthisstudy,weaimedtoinvestigatetheeffectsofactivatingPPARγonpulmonaryvascula