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去分化脂肪细胞与脂肪干细胞成骨成软骨能力的比较研究.docx

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去分化脂肪细胞与脂肪干细胞成骨成软骨能力的比较研究 Title:ComparativeStudyontheOsteogenicandChondrogenicAbilitiesofDifferentiatedAdipocytesandAdipose-derivedStemCells Abstract: Theabilityofadipocytesandadipose-derivedstemcells(ADSCs)todifferentiateintoboneandcartilagehasattractedsignificantattentioninbothclinicalandresearchsettings.ThisstudyaimstocompareandevaluatetheosteogenicandchondrogenicpotentialofdifferentiatedadipocytesandADSCstoprovidevaluableinsightsintoregenerativemedicineandtissueengineeringapplications.Throughanin-depthanalysisofrelevantliterature,thispaperexaminesthedifferentiationprocess,molecularmechanisms,andpotentialfuturedevelopmentsinthefieldofadipocyteandADSCdifferentiationforboneandcartilageformation.Thefindingscontributetoabetterunderstandingofadiposetissue'sregenerativecapacityanditspotentialroleintreatingboneandcartilage-relateddisorders. Introduction: Adiposetissuehasemergedasanabundantandreadilyaccessiblesourceofmultipotentcells,includingadipocytesandADSCs,capableofdifferentiatingintovariouscelllineages.Previousstudieshaveshownpromisingresultsregardingtheregenerativepotentialofadiposetissueinboneandcartilagerepair.ThisresearchaimstocomparetheosteogenicandchondrogenicabilitiesofdifferentiatedadipocytesandADSCs,sheddinglightontheirdifferentiationpotentialandguidingfuturetherapeuticstrategies. DifferentiationProcessofAdipocytesandADSCs: AdipocytesandADSCsshareacommonprecursor,knownaspreadipocytes.Underspecificconditions,preadipocytescanundergolineagecommitmentanddifferentiationintoadipocytesorADSCs.Adipocytedifferentiationismainlygovernedbyseveralkeytranscriptionfactors,suchasperoxisomeproliferator-activatedreceptorgamma(PPARγ)andCCAAT/enhancer-bindingproteins(C/EBPs).Incontrast,ADSCsrequireadditionalgrowthfactorsandsignalstodifferentiateintotheosteogenicorchondrogeniclineages. OsteogenicPotential: ResearchsuggeststhatdifferentiatedadipocyteshavealimitedabilitytoundergoosteogenesiscomparedtoADSCs.ADSCspossessthecapacitytodifferentiateintoosteoblasts,thebone-formingcell