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过渡金属催化卡宾前体参与的导向碳氢键活化反应研究的开题报告.docx

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过渡金属催化卡宾前体参与的导向碳氢键活化反应研究的开题报告 Abstract Transitionmetal-catalyzedcarbeneprecursorshavebecomeapromisingtoolinorganicsynthesis.Theyofferavarietyofreactionsandtransformations,oneofwhichisthedirectedC-Hactivation.ThisprocessinvolvestheactivationofaspecificC-Hbond,resultingintheformationofanewC-Cbond.Inthisreport,wewillexplorethecurrentstateofresearchinthisfield,includingthevariousmethodsemployedandthechallengesthatremaintobeaddressed. Introduction C-Hactivationisaversatiletransformationthathasrevolutionizedthefieldoforganicsynthesis.ItallowsfortheselectivefunctionalizationofaspecificC-Hbond,withoutrequiringtheuseofprefunctionalizedstartingmaterials.Overtheyears,severalstrategieshavebeendevelopedforC-Hactivation,includingtheuseoftransitionmetalcatalysts,whichprovideapowerfulmeansforcontrollingthereactivityofC-Hbonds.Amongthesemethods,theuseoftransitionmetal-catalyzedcarbeneprecursorshasemergedasapowerfultoolfordirectedC-Hactivation. Transitionmetal-catalyzedcarbeneprecursorsarerelativelystable,andcanbepreparedfromeasilyaccessiblestartingmaterials.Theycanbereadilyfunctionalized,andofferavarietyofreactionsandtransformations.OneofthemostpromisingoftheseisdirectedC-Hactivation.Inthisprocess,atransitionmetal-catalyzedcarbeneprecursorisusedtoactivateaspecificC-Hbond,leadingtotheformationofanewC-Cbond.ThismethodoffersseveraladvantagesovertraditionalmethodsforC-Hactivation,includingincreasedselectivityandmildreactionconditions. CurrentStateofResearch TherehavebeenseveralreportsondirectedC-Hactivationusingtransitionmetal-catalyzedcarbeneprecursors.Themostcommonlyusedprecursorsarediazocompounds,whichcanbegeneratedfromavarietyofstartingmaterialssuchassulfones,sulfoxides,anddiazoacetates.SeveraltransitionmetalshavebeenexploredfortheirabilitytoactivateC-HbondsincludingRh,Ir,Ru,andCo.Thechoiceoftransitionmetaldependsonthesubstratebeingused,aswellasthedesiredproduct. OneofthemoststudiedsystemsisthereactionofdiazoacetateswithRhorIrcatalyststogeneratemetalcarbenes,whichcanthenactivateC-Hb