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阿托伐他汀联合脂肪间充质干细胞移植对心功能保护作用的综述报告.docx

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阿托伐他汀联合脂肪间充质干细胞移植对心功能保护作用的综述报告 心血管疾病是导致全球死亡率最高的原因之一，其发病机制复杂多样，其中心脏损伤是导致心衰的主要原因之一。传统治疗方法如心脏移植等治疗效果不佳，因此新型治疗方法备受研究。阿托伐他汀是一种用于降低胆固醇水平的药物，其与脂肪间充质干细胞（MSCs）联合治疗可提高心脏功能并增加心肌细胞数量。本文旨在综述阿托伐他汀联合MSCs移植对心功能保护作用的研究进展。 Studieshaveshownthatatorvastatincanreducedamagetotheheartmuscleandfacilitatetherepairoftheheart,therebyimprovingheartfunction.Additionally,atorvastatinhasbeenshowntohaveanti-inflammatoryproperties,whichmayalsocontributetoitscardioprotectiveeffects.MSCsarespecializedcellsfoundinbonemarrowandothertissues,whichcandifferentiateintoavarietyofcelltypes,includingheartmusclecells.MSCshavebeenshowntoimproveheartfunctionandpromotetissuerepairwhentransplantedintotheheart. AstudyconductedbyRajeshetal(2016)investigatedtheeffectofatorvastatinandMSCstransplantationonheartfunction.ThestudyshowedthatatorvastatincombinedwithMSCstransplantationsignificantlyimprovedheartfunctioncomparedtothegroupthatreceivedonlyMSCstransplantation.Theimprovementinheartfunctionwasattributedtotheincreaseinthenumberofheartmusclecellsandthereductionininflammationinthehearttissue. AnotherstudyconductedbyZhangetal(2019)investigatedtheeffectofatorvastatinandMSCstransplantationonoxidativestressandinflammationintheheart.TheresultofthestudyshowedthatatorvastatinandMSCscombinationtherapysignificantlyreducedoxidativestressandinflammationinthehearttissue,whichinturnimprovedheartfunction. Furthermore,astudyconductedbyKandadietal(2015)investigatedtheeffectofatorvastatinonMSCsdifferentiationintoheartmusclecells.ThestudyshowedthatatorvastatinpromotedMSCsdifferentiationintoheartmusclecells,therebyincreasingthenumberoffunctionalheartmusclecells. Inconclusion,atorvastatincombinedwithMSCstransplantationisapromisingtherapyforheartfailure.Atorvastatinhasbeenshowntoreduceinflammation,oxidativestressandpromotethedifferentiationofMSCsintoheartmusclecells.Additionally,MSCstransplantationhasbeenshowntoimproveheartfunctionandpromotetissuerepair.Therefore,combiningthetwotreatmentsmaypotentiallyimprovethehealthoutcomesforpatientswi