肿瘤的生物学特性ppt课件.ppt

肿瘤的生物化学特性物质代谢及酶的变化.核酸代谢DNA拓扑异构酶(A)ClassificationofhumanDNAtopoisomerases.TypeIBaretheonlyenzymesthatformcleavagecomplexes(cc)with30-phosphotyrosyl(30-P-Y)intermediates..Itisthoughtthatlengthorintegrityofchromosome
endisusedasamitoticcountingmechanism
invitroMammalianhaveastretchofasimplerepeatsequence
unit(TTAGGG)andin,lengthis15–20kb.
Fiftyto200bpofthetelomericDNAshortensateach
roundofmitosis.WhenaverageDNAreachesa
criticallyshortlength,about4–7kb,isarrested
Irreversibly.物质代谢及酶的变化物质代谢及酶的变化肿瘤细胞的分化稳定性
全能性
选择性
条件可逆性肿瘤细胞分化异常的机制肿瘤细胞的生长肿瘤细胞的生长肿瘤细胞的生长CyclinEwasprognosticinsevenoutof10studies.CyclinD1AstrongcorrelationbetweenoverexpressionofcyclinD1andHR-positivityhasbeenreportedinthemajorityoftrials,butcyclinD1doesnotappeartobeastrongprognostic
marker.Infact,itsoverexpressionhasbeenassociatedwithbetterRFSinonlyonestudy肿瘤的生长与扩散转移Figure1.Developmentoflymphaticvesselsinembryogenesisandcancer
Someoftheproteinsthatareimportantinthese
eventsareshownunderneatheachsection.
Arrowsdenotethedirectionoflymphflowinthe
lymphaticvessels.转移转移肿瘤细胞扩散的过程机制肿瘤细胞扩散的过程机制肿瘤细胞扩散的过程机制肿瘤细胞扩散的过程机制肿瘤细胞扩散的过程机制transientadhesiveinteractionsbycellswithendothelial
selectins(rolling),andfirmlyanchoredon(firmadhesion)
toenableentryintotheunderlyingtissue.Theselectins,
particularlyE-selectin,arerecognizedtomediate
adhesionandthuspotentiateofcertaincancers肿瘤细胞扩散的过程机制肿瘤细胞扩散的过程机制肿瘤细胞向周围组织的浸润肿瘤血管生成肿瘤血管生成Fig.1Switchingontheangiogenicphenotypeintumorsbygeneticandepigeneticfactors.Bothmalignantandnonmalignantcellsproducemultipleangiogenicfactorsandcytokinestoinducetumorneovascularization.Endogenousangiogenesisinhibitorsaredownregulatedtosupporttheangiogenicphenotype肿瘤细胞侵入血管和淋巴管转移灶的形成和生长肿瘤侵袭和转移相关基因肿瘤侵袭和转移相关基因肿瘤侵袭和转移相关基因RESULTS:
Tiam1overexpressionsignificantlyincreasedtheabilitiesof
adhesion,migratoryandinvasionofC666-1andCNE1cells,
comparingwiththatofthecontroluntransfectedcells
(P<0.05).
CONCLUSION:
Tiam1expressioncorrelateswiththeinvasionandmetastasis
ofnasopharyngealcarcinomacells.OverexpressionofTiam1inhepatoce