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异甘草素体外抗肿瘤活性及作用机制研究的综述报告.docx

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异甘草素体外抗肿瘤活性及作用机制研究的综述报告 异甘草素是从甘草根部提取得到的一种天然化合物，具有多种生物活性，如抗氧化、抗炎、抗微生物等。近年来，其抗肿瘤活性备受关注。本文将从异甘草素的体外抗肿瘤活性和作用机制两个方面进行综述。 一、异甘草素的体外抗肿瘤活性 1.抑制细胞增殖和诱导细胞凋亡 Studieshaveshownthatisoliquiritigeninexhibitsstrongantiproliferativeandproapoptoticeffectsinvariouscancercelllines.Forexample,isoliquiritigenincaninhibittheproliferationofbreastcancercellsinadose-andtime-dependentmannerandinducecellcyclearrestintheG2/Mphase.Moreover,isoliquiritigenincaninduceapoptosisinbreastcancercellsviatheactivationofcaspase-3andtheBax/Bcl-2pathway. Inaddition,isoliquiritigeninhasbeenreportedtoexhibitpotentantiproliferativeeffectsinhumanlungcancercells,colonadenocarcinomacells,gastriccancercells,andprostatecancercells.Theunderlyingmechanismofitsantiproliferativeactivityismainlyattributedtotheinductionofapoptosis,cellcyclearrest,andinhibitionofthePI3K/AktandNF-κBsignalingpathways. 2.抑制肿瘤细胞侵袭和转移 Metastasisisamajorcauseofcancer-relatedmorbidityandmortality.Studieshavefoundthatisoliquiritigenincaninhibittheinvasionandmetastasisofvariouscancercells.Forexample,isoliquiritigenincanreducethemigrationandinvasionofbreastcancercellsthroughthedownregulationofMMP-9expressionandtheinhibitionofthePI3K/AktandERKsignalingpathways.Similarly,isoliquiritigenincanalsoinhibitthemigrationandinvasionofhumanlungcancercellsandgastriccancercellsbydownregulatingthelevelsofMMP-2andMMP-9. 3.抑制肿瘤血管生成 Angiogenesis,theformationofnewbloodvessels,playsacrucialroleintumorgrowthandmetastasis.Studieshaveshownthatisoliquiritigenincaninhibitangiogenesisbytargetingvarioussignalingpathways.Forinstance,isoliquiritigenincandownregulatetheexpressionofVEGF,akeyfactorinangiogenesis,inbreastcancercellsandhumanumbilicalveinendothelialcells.Moreover,isoliquiritigenincaninhibittheactivationoftheAktandERKsignalingpathways,whichareinvolvedintheregulationofangiogenesis. 4.其他作用 Inadditiontotheabove-mentionedantitumoreffects,isoliquiritigeninhasbeenreportedtoexertotheractivities,suchasmodulatingtheimmuneresponse,enhancingthesensitivityofcancercellstochemoth