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小RNA表达测定方法MicroRNAExpressionDetection.doc

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MicroRNAExpressionDetectionMethods ZhiguoWang l BaofengYang MicroRNAExpression DetectionMethods Dr.ZhiguoWang MontrealHeartInstitute ResearchCenter 5000BelangerStreet MontrealQCH1T1C8 Canada zhiguo.wang@icm-mhi.org or wangz@mirna-tech.com Dr.BaofengYang HarbinMedicalUniversity Dept.Pharmacology 150086Harbin China,People’sRepublic yangbf@ems.hrbmu.edu.cn ISBN:978-3-642-04927-9e-ISBN:978-3-642-04928-6 DOI10.1007/978-3-642-04928-6 SpringerHeidelbergDordrechtLondonNewYork LibraryofCongressControlNumber:PCNAppliedfor #Springer-VerlagBerlinHeidelberg2010 Thisworkissubjecttocopyright.Allrightsarereserved,whetherthewholeorpartofthematerialis concerned,speci?callytherightsoftranslation,reprinting,reuseofillustrations,recitation,broadcasting, reproductiononmicro?lmorinanyotherway,andstorageindatabanks.Duplicationofthispublication orpartsthereofispermittedonlyundertheprovisionsoftheGermanCopyrightLawofSeptember9, 1965,initscurrentversion,andpermissionforusemustalwaysbeobtainedfromSpringer.Violations areliabletoprosecutionundertheGermanCopyrightLaw. Theuseofgeneraldescriptivenames,registerednames,trademarks,etc.inthispublicationdoesnot imply,evenintheabsenceofaspeci?cstatement,thatsuchnamesareexemptfromtherelevantprotec- tivelawsandregulationsandthereforefreeforgeneraluse. Coverdesign:WMXDesignGmbH,Heidelberg,Germany Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) Preface MicroRNAs(miRNAs),endogenousnoncodingregulatorymRNAsof22- nucleotides,haverapidlyemergedasthecentralplayersingeneexpression regulation.Owingtotheirever-increasingimplicationsinthecontrolofvarious biologicalandpathologicalprocesses,miRNAshavenowbeenconsiderednovel biomarkersofvarioushumandiseasesincluding,cancer,viraldisease,cardiovas- culardisorders,metabolicdisturbances,etc.Particularexpressionpro?leshave beenassociatedwithparticularpathologicalstates.Expressionpro?lingofmiR- NAshavethereforebecomeextremelyimportantnotonlyf