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细胞凋亡的线粒体途径.ppt

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报告提纲细胞死亡细胞凋亡的特征Fig.1.Schematicsummaryofbiochemicalmechanismsofapoptosis.MitochondriaandCommitmenttoCellDeathMitochondriaandCommitmenttoCellDeathMitochondrialPathwaysinphysiologicalcelldeathMitochondrialPathwaysinphysiologicalcelldeathDisruptionofelectrontransportandenergymetabolismDisruptionofelectrontransportandenergymetabolismDisruptionofelectrontransportandenergymetabolismReleaseofcaspase-activatingproteinsReleaseofcaspase-activatingproteinsReactiveoxygenspeciesandcellularredox.Reactiveoxygenspeciesandcellularredox.PTPorePTPorePTPore的性质PTPore有开放与关闭二种构象Figure2.Themitochondrialpermeabilitytransition.Fig.4Thecytochromec-inducedcaspaseactivationpathway.Figure1.Thecytochromec-inducedcaspaseactivationpathway.Fig.5.DisplacementofIAPsfromcaspasesbySmac/Diablo.Figure2.DisplacementofIAPsfromcaspasesbySmac/Diablo.Fig.6.Multipleapoptoticpathwaysemanatefromthemitochondria.Figure3.Multipleapoptoticpathwaysemanatefromthemitochondria.Thanks!