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溶胶凝胶法载银抗菌研究.pdf

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AntimicrobialEffectsandHumanGingivalBiocompatibilityof HydroxyapatiteSol–GelCoatings Ren-JeiChung,1Ming-FaHsieh,2,*Chine-WenHuang,1Li-HsiangPerng,3Hsiao-WeiWen,4 Tsung-ShuneChin1 1DepartmentofMaterialsScienceandEngineering,NationalTsingHuaUniversity,101,Sec2,Kuang-FuRoad,Hsinchu 300,Taiwan,RepublicofChina 2BiomedicalEngineeringCenter,IndustrialTechnologyResearchInstitute,195ChungHsingRoad,Sec4ChuTung, Hsinchu310,Taiwan,RepublicofChina 3DepartmentofChemicalEngineering,ChengShiuUniversity,840,ChengcingRoad,NiaosongTownship,Kaohsiung83305, Taiwan,RepublicofChina 4NuclearScienceandTechnologyDevelopmentCenter,NationalTsingHuaUniversity,101,Sec2,Kuang-FuRoad,Hsinchu 300,Taiwan,RepublicofChina Received7December2004;revised27March2005;accepted6April2005 Publishedonline3August2005inWileyInterScience(www.interscience.wiley.com).DOI:10.1002/jbm.b.30365 Abstract:Thesol–gelmethodwasemployedtosynthesizehydroxyapatite(HAp)coatings modifiedwithAgorZnionsontoTi-6Al-4Vsubstrate.AbacterialstrainStreptococcusmutans (S.mutans)andahumangingivalfibroblast(HGF-1)celllinewereusedtoinvestigatethe antimicrobialeffectandbiocompatibility,respectively.HApcoatingscontaining100ppmAg؉ ionssuppressedthegrowthofS.mutans.AnapparentinhibitionzonearoundtheHApcoating -wasfurtherobservedatAg؉concentrationupto10,000ppm.However,forcoatingscontain .ingZn2؉ions,aclearinhibitionzonewasobservedatZn2؉concentrationof10,000ppm Nevertheless,theresultsofHGF-1cultivationdemonstratedthattheZn2؉-modifiedHAp -coatingsexhibitedbetterattachmentandspreadofHGF-1thandidtheAg؉-modifiedcoat ings.Zn2؉modifiedHApcoatingsalsoincreasedtheplatingefficiencyofHGF-1cells.The cytotoxicityassociatedwiththeadditionofAgandthecell-conductivecapacityassociatedwith theadditionofZnareproportionaltotheaddedconcentration,from100to10,000ppm.The dosagesofbothAg؉andZn2؉ionsthatshouldbeaddedtoHApcoatingswereconsideredto preventinfectionandimprovebiocompatibility.TheresultsofthisstudyensurethatHAp coatingsmodifiedwithamoderateamountofAg/Znefficientl