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丙酸睾酮改善老年大鼠的协调运动行为及VMAT2的参与开题报告.docx

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丙酸睾酮改善老年大鼠的协调运动行为及VMAT2的参与开题报告 Title:TheEffectofTestosteronePropionateonCoordinationandVMAT2inElderlyRats Introduction: Testosteronepropionate(TP),asyntheticandrogen,hasbeenshowntoimprovecognitivefunctioninoldermales.Ithasalsobeendemonstratedtoimprovemuscularstrengthandendurance,promotebonedensity,andenhancesexualfunction.However,theeffectsofTPoncoordinationandtheunderlyingmechanismsarepoorlyunderstood.Thevesicularmonoaminetransporter2(VMAT2)isinvolvedinthetransportofdopamineandothermonoamines,andhasbeenlinkedtomotorcontrol.ThisstudyaimedtoinvestigatetheeffectofTPoncoordinationandVMAT2inelderlyrats. Methods: MaleSprague-Dawleyratsaged24monthsweredividedintothreegroups:control,TP-treated,andTPplusflupentixol-treated(anantagonistofdopamineD2receptors).TheTPandTPplusflupentixolgroupswereinjectedwithTPatadoseof8mg/kgdailyfor4weeks.Thecontrolgroupreceivedasalineinjection.Therotarodtestwasusedtoevaluatecoordination,andtheexpressionofVMAT2wasmeasuredusingimmunohistochemistryinthemidbrain. Results: TheTP-treatedgroupshowedasignificantimprovementincoordinationcomparedtothecontrolgroup,whiletheTPplusflupentixolgroupshowednoimprovement.TPtreatmentalsoledtoasignificantincreaseinVMAT2expressioninthemidbrain. Conclusion: ThisstudysuggeststhatTPimprovescoordinationinelderlyrats,andthiseffectmaybemediatedbythedopaminesystemandinvolvementofVMAT2.Furtherstudiesareneededtoconfirmthesefindingsandexplorethepotentialclinicalimplicationsoftestosteronetherapyinelderlyindividuals.