帕利哌酮缓释片对催乳素及糖脂代谢的影响.pdf

172JClinPsychiatry,2010,Vol20,No.3
论著
帕利哌酮缓释片对催乳素及糖脂代谢的影响

刘艳红,陈景旭,卞清涛,王宁,吕建宝,杨甫德

摘要:目的:探讨帕利哌酮缓释片治疗精神分裂症患者前后催乳素(PRL)及糖脂水平的变化。
方法:47例精神分裂症患者接受帕利哌酮缓释片治疗8周。于治疗前和治疗4、8周抽取空腹血测定
PRL、胰岛素(INS)、血糖(FBS)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL)、低密度脂
蛋白胆固醇(LDL)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)水平,同时测量患者腹围及体质量变化。
结果:治疗4周和8周,男性患者PRL水平由治疗前(31.5319.27)ng/ml分别升高至(42.24
18.45)ng/ml和(40.4726.53)ng/ml(P<0.01);女性患者PRL水平由(78.1348.70)ng/ml分别升
高至(138.3858.92)ng/ml和(135.1256.47)ng/ml(P<0.01);以女性患者PRL水平较男性患者升
高显著(P<0.01)。PRL水平与帕利哌酮缓释片剂量相关性无统计学意义(P均>0.05)。比较治疗前
和治疗4、8周后FBS、INS、TG、TC、HDL、LDL、ApoA1、ApoB水平及患者腹围、体质量的变化,差异均无统
计学意义(P均>0.05)。结论:帕利哌酮缓释片可明显升高血清PRL水平,以女性患者升高显著,而
对糖脂代谢的影响较小。
关键词:帕利哌酮;催乳素;血糖;血脂
中图分类号:R749.053文献标识码:A文章编号:10053220(2010)03017202

Theeffectsofpaliperidonrretardtabletsonprolactin,glucoseandlipidmetabolismLIUYanhong,
CHENJingxu,BIANQingtao,WANGNing,LVJianbao,YANGFude.BeijingHuilongguanHospital,Beijing
100096,China
Abstract:Objective:Toexploreeffectsofpaliperidoneretardtabletsonprolactin(PRL),glucoseand
lipidmetabolisminschizophrenicpatients.Method:47schizophrenicpatientswererecruitedtotakepartin
an8weekopenlabeltrialofpaliperidoneretardtablets.Atbaseline,week4andweek8,PRL,bloodfasting
sugar(BFS),insulin(INS),totalcholesterol(TC),triglyceride(TG),highdensitylipoprotein(HDL),lowden
sitylipoprotein(LDL),apolipoproteinA1(APOA1),apolipoproteinB(APOB),waistlineandbodyweightwere
measured.Results:PRLlevelrosefrom(31.5319.27)ng/mlatbaselineto(42.2418.45)ng/mlatweek
4andto(40.4726.53)ng/mlatweek8inmen;andfrom(78.1348.70)ng/mlatbaselineto(138.38
58.92)ng/mlandto(135.1256.47)ng/mlinwomen.Womenshowedmoresignificantincreasesthanmen(P<
0.01).ThelevelsofFBS,INS,TG,HDL,LDL,APOA1,APOB,waistlineandbodyweightdemonstratednosig
nificantchangesafterthetreatment(P>0.05).Conclusion:Paliperidoneretardtabletsmayinducehyperpro
lactinemia,especiallyforwomen,withlittleinfluenceonthemetabolicbloodglucoseandlipid.
Keywords:paliperidone;prolactin;bloodfastingsugar;bloodlipid

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