环氧化酶22蛋白在膀胱移行细胞癌中的表达及意义.pdf

第41卷第3期青岛大学医学院学报Vol.41,No.3
2005年9月ACTAACADEMIAEMEDICINAEQINGDAOUNIVERSITATISSeptember2005

环氧化酶22蛋白在膀胱移行细胞癌中的表达及意义

罗波,张劲峰
(青岛大学医学院松山医院泌尿外科,山东青岛266021)

[摘要]①目的探讨环氧化酶22(COX22)蛋白在膀胱移行细胞癌(TCCB)中的表达及其与肿瘤生物学行为
之间的关系。②方法采用免疫组化SP法检测120例膀胱移行细胞癌和10例正常膀胱黏膜标本COX22蛋白的

表达。③结果正常膀胱黏膜COX22呈阴性表达,在膀胱移行细胞癌G1、G2、G3级和Tis～T1、T2～T4期阳性表
达率分别为40.00%、61.02%、93.75%和44.83%、90.91%,COX22的阳性率在不同组织学分级的TCCB中差异
有极显著性(χ2=13.96,P<0.01),在不同临床分期的TCCB中差异有极显著性(χ2=20.70,P<0.01),在复发组
与未复发组COX22阳性率分别为82.50%和45.00%,差异有极显著性(χ2=15.35,P<0.01)。④结论COX22
阳性表达与膀胱移行细胞癌病理分级、浸润及复发关系密切,COX22可以作为判定膀胱移行细胞癌恶性程度及复
发的参考指标。
[关键词]环氧化酶;膀胱肿瘤;免疫组织化学;预后
[中图分类号]R737.14[文献标识码]A[文章编号]167224488(2005)0320235203

EXPRESSIONOFCYCLOOXYGENASE22INTRANSITIONALCELLCARCINOMAOFTHEBLADDERANDITSSIGNIFICANCE
LUOBo,ZHANGJin2feng(DepartmentofUrology,SongshanHospital,QingdaoUniversityMedicalCollege,Qingdao
266021,China)
[ABSTRACT]ObjectiveTostudytheexpressionofcyclooxygenase22(COX22)intransitionalcellcarcinomaofthebladder
(TCCB)andanalyzeitscorrelationwiththebiologicalbehaviorofthetumor.MethodsTheexpressionsofCOX22in120casesof

TCCBand10casesofnormalbladderTissueweredetectedbystreptavidin2peroxidaseimmunohistochemicalmethod.Results
COX22wasnegativelyexpressedinnormalbladdermucosa.ThepositiveexpressionratesofCOX22were40.00%,61.02%and

93.75%forG1,G2andG3,44.83%and90.91%forTis-T1andT2-T4tumors,respectively.Thepositiveexpressionsinthree
groupswithdifferenthistologicalgradinginTCCBshowedsignificantdifference(χ2=13.96,P<0.01),andthedifferenceshowed
greatsignificanceaswellintwodifferentclinicalstaging(χ2=20.70,P<0.01).TheexpressionofCOX22inrecurrencegroupand
non2recurrencegroupwas82.50%and45.00%,respectively,andthedifferencewassignificant(χ2=15.35,P<0.01).Conclu2
sionThepositiveexpressionofCOX22inTCCBiscloselyrelatedtothetumor2cellgrade,depthofinvasionandrecurrence.The
expressionofCOX22maybeusedasaparameterforassessingthemalignancyandrecurrenceofTCCB.
[KEYWORDS]cyclooxygenase22;bladderneoplasms;immunohistochemistry;prognosis

环氧化酶22(COX22)作为前列腺素合成过程中理分