干细胞-脑肿瘤干细胞-脑肿瘤干细胞的研究现状.pdf

中国组织工程研究第16卷第14期2012–04–01出版
ChineseJournalofTissueEngineeringResearchApril1,2012Vol.16,No.14

脑肿瘤干细胞的研究现状★

12
王欣欣，刘季平

Researchprogressinbraintumorstemcells

12
WangXin-xin,LiuJi-ping

Abstract
1
BACKGROUND:Researchinrecentyearshasdiscoveredsomestemcell-likecellsexistinbraintumors,whichhavetheDepartmentof
propertiesofendlesscellproliferation,uncontrolledself-renewalandmulti-directionaldifferentiation,andtheyarecalledasbrainPathology,Baotou
MedicalCollegeof
tumorstemcells.Braintumorstemcellsplayakeyroleintheprogressoftumorigenesis,growth,invasion,metastasisandInnerMongolia
recurrence.UniversityofScience
OBJECTIVE:Toconcludeandexplorethecurrentstudiesonbraintumorstemcells.andTechnology,
METHODS:Acomputer-basedsearchofPubmedDatabasewasperformedtoretrieverelevantarticlesaboutbraintumorandBaotou014010,
InnerMongolia
braintumorstemcellspublishedfromJanuary1977toJuly2011.BooksonstemcellsandbraintumorstemcellswerealsoAutonomousRegion,
2
retrieved.Thedatawereselectedprimarily,and32articlesrelatedtobraintumorstemcellswereselected.China;Department
RESULTSANDCONCLUSION:Braintumorstemcellsexistinmalignantbraintumor,andtheyaretheoriginoftheoccurrence,ofNeurosurgery,Staff
development,metastasisandrecurrenceofmalignantbraintumor.BraintumorstemcellsexpressCD133,NestinproteinandHospitalofInner
MongoliaNorth
ABCtransporterinmalignantbraintumors.Recently,asimplemethodhasbeenobtainedtoisolatebraintumorstemcells.TheHeavyIndustries
proportionofCD133positivetumorstemcellsispositivelycorrelatedwiththeseverityofmalignantbraintumors,whichcanbeGroupCo.,Ltd.,
usedasadiagnosticindicatorofprognosis.Baotou014030,
InnerMongolia

AutonomousRegion,

WangXX,LiuJP.Researchprogressinbraintumorstemcells.ZhongguoZuzhiGongchengYanjiu.2012;16(14):2637-2640.China
[http://www.crter.cnhttp://en.zglckf.com]
WangXin-xin★,

Master,Lecturer,
摘要Departmentof
背景：在脑肿瘤中存在一种具有自我更新、无限增殖与多向分化能力的细胞，即脑肿瘤干细胞。脑肿瘤干细胞被认为是脑Pathology,Baotou
MedicalCollegeof
肿瘤发生、发展、转移与复发的根源。InnerMongolia
目的：总结和探讨脑肿瘤干细胞的研究现状。UniversityofScience