预览加载中，请您耐心等待几秒...

肿瘤与代谢.pptx

预览
1/10
2/10
3/10
4/10
5/10
6/10
7/10
8/10
9/10
10/10

亲，该文档总共35页，到这已经超出免费预览范围，如果喜欢就直接下载吧～

下载提示 文本预览

如果您无法下载资料，请参考说明：

1、部分资料下载需要金币，请确保您的账户上有足够的金币

2、已购买过的文档，再次下载不重复扣费

3、资料包下载后请先用软件解压，在使用对应软件打开

肿瘤与代谢Potentialtargetsforcancertherapyfoundwithinmetabolicpathwaysinvolvedinglucosemetabolism.突变（Mutation）？瓦尔堡(Warburg)假说Warburg效应糖酵解的意义PET原理WarburgeffectWarburgeffectTumormicroenvironmentandstabilizationofHIFMicroenvironmentCancercellsareknowntoadapttothehypoxicconditionviathehypoxia-induciblefactor1(HIF-1).HIF-1isaheterodimerictranscriptionfactorOncogenesandtumorsuppressorgenesMitochondrialdysfunctionRedoxalterationsinducedbyTCAcycledefects.RedoxalterationsinducedbymutationsinSDH,FH,andIDHareshown.LossoffunctionofSDHincreasesROSlevelsleadingtoDNAmutationsandHIF-1αstabilization.IDH1andmutationsdecreaseGSHandNADPHlevels.NuclearDNAmutations关于IDH突变IDH突变与胶质瘤IDH1andIDH2MutationsinHumanGliomasSurvivalofAdultPatientswithMalignantGliomaswithorwithoutIDHGeneMutationsmiRNAGlutaminemetabolismTargetingtheWarburgphenomenonforcancertherapyAbbreviations:2-DG,2-deoxyglucose;LND,lonidamine;3-BrPA,3-bromopyruvate;3-PO, 3-(3-pyridinyl)-l-(4-pyridinyl)-2-propen-l-one;6-AN,6-aminonicotinamide;DCA, dichloroacetate;GA,geldanamycin;2ME2,2-methoxyoestradiol;PX-478,S-2-amino- 3-[4′-N,N,-bis(2-chloroethyl)amino]phenylpropionicacidN-oxidedihydrochloride.2-DG(2-deoxyglucose)Px-478